OR2T4

OR2T4
Identifiers
Aliases	OR2T4 , OR1-60, OR2T4Q, olfactory receptor family 2 subfamily T member 4
External IDs	MGI: 3030058 HomoloGene: 133015 GeneCards: OR2T4
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q44 Start 248,361,665 bp [1] End 248,362,627 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B1.3 Start 58,456,682 bp [2] End 58,461,379 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence prefrontal cortex Brodmann area 9 substantia nigra Top expressed in esophagus conceptus placenta More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 127074 258198 Ensembl ENSG00000196944 ENSG00000275617 ENSG00000274870 ENSMUSG00000059279 UniProt Q8NH00 M9MMJ7 RefSeq (mRNA) NM_001004696 NM_207695 RefSeq (protein) NP_001004696 NP_997578 Location (UCSC) Chr 1: 248.36 – 248.36 Mb Chr 11: 58.46 – 58.46 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 2T4 is a protein that in humans is encoded by the OR2T4 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

Ligands

OR2T4 has known odorant ligands, many of which have a "floral", "soapy", or "waxy" character, similar to lily of the valley:

• Farnesol
• Lilial
• Undecanal ^[6]

See also

• Olfactory receptor

References

1. ENSG00000275617, ENSG00000274870 GRCh38: Ensembl release 89: ENSG00000196944, ENSG00000275617, ENSG00000274870 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000059279 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR2T4 olfactory receptor, family 2, subfamily T, member 4".
6. Yasi EA, Eisen SL, Wang H, Sugianto W, Minniefield AR, Hoover KA, Branham PJ, Peralta-Yahya P (2019). "Rapid Deorphanization of Human Olfactory Receptors in Yeast". Biochemistry. 58 (16): 2160–2166. doi:10.1021/acs.biochem.8b01208. PMC   6482435 . PMID   30977365.

Further reading

• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR2T4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.