OR5B12

OR5B12
Identifiers
Aliases	OR5B12 , OR11-241, OR5B12P, OR5B16, OST743, olfactory receptor family 5 subfamily B member 12
External IDs	MGI: 3031279 HomoloGene: 133606 GeneCards: OR5B12
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q12.1 Start 58,438,994 bp [1] End 58,442,236 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19|19 A Start 12,861,219 bp [2] End 12,862,219 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node gallbladder human musculoskeletal system muscle of leg gastrocnemius muscle n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity odorant binding olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 390191 258694 Ensembl ENSG00000172362 ENSMUSG00000045126 UniProt Q96R08 Q8VFW9 RefSeq (mRNA) NM_001004733 NM_146699 RefSeq (protein) NP_001004733 NP_666910 Location (UCSC) Chr 11: 58.44 – 58.44 Mb Chr 19: 12.86 – 12.86 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 5B12 is a protein that in humans is encoded by the OR5B12 gene. ^{[5] [6]}

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[6]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000172362 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000045126 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, Shmulevich D, Elkon R, Steinfath M, O'Brien JK, Radelof U, Lehrach H, Lancet D, Shamir R (Sep 2002). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. CiteSeerX   10.1.1.145.6233 . doi:10.1006/geno.2002.6830. PMID   12213199.
6. "Entrez Gene: OR5B12 olfactory receptor, family 5, subfamily B, member 12".

Further reading

• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR5B12+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.