OR11A1

OR11A1
Identifiers
Aliases	OR11A1 , 6M1-18, OR11A2, dJ994E9.6, hs6M1-18, olfactory receptor family 11 subfamily A member 1
External IDs	MGI: 2177479 HomoloGene: 27189 GeneCards: OR11A1
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p22.1 Start 29,425,504 bp [1] End 29,457,071 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 B1 Start 37,531,037 bp [2] End 37,537,564 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle Top expressed in respiratory epithelium peripheral nervous system olfactory epithelium blastocyst More reference expression data BioGPS n/a
Gene ontology Molecular function olfactory receptor activity signal transducer activity G protein-coupled receptor activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell detection of chemical stimulus involved in sensory perception of smell signal transduction response to stimulus G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26531 258507 Ensembl ENSG00000237258 ENSG00000230780 ENSG00000232289 ENSG00000234347 ENSG00000223898 ENSG00000206517 ENSG00000206472 ENSG00000204694 ENSMUSG00000064121 UniProt Q9GZK7 Q8VFE3 RefSeq (mRNA) NM_013937 NM_001394828 NM_001394829 NM_146514 RefSeq (protein) NP_039225 NP_666725 Location (UCSC) Chr 6: 29.43 – 29.46 Mb Chr 17: 37.53 – 37.54 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 11A1 is a protein that in humans is encoded by the OR11A1 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. ENSG00000230780, ENSG00000232289, ENSG00000234347, ENSG00000223898, ENSG00000206517, ENSG00000206472, ENSG00000204694 GRCh38: Ensembl release 89: ENSG00000237258, ENSG00000230780, ENSG00000232289, ENSG00000234347, ENSG00000223898, ENSG00000206517, ENSG00000206472, ENSG00000204694 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000064121 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR11A1 olfactory receptor, family 11, subfamily A, member 1".

Further reading

• Volz A, Ehlers A, Younger R, et al. (2003). "Complex transcription and splicing of odorant receptor genes". J. Biol. Chem. 278 (22): 19691–701. doi: 10.1074/jbc.M212424200 . PMID   12637542.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR11A1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.