OR10A3

OR10A3
Identifiers
Aliases	OR10A3 , HSHTPCRX12, HTPCRX12, olfactory receptor family 10 subfamily A member 3
External IDs	MGI: 3030352 HomoloGene: 133601 GeneCards: OR10A3
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.4 Start 7,937,171 bp [1] End 7,941,708 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 E3 Start 108,479,395 bp [2] End 108,484,213 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen placenta n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26496 258303 Ensembl ENSG00000273953 ENSG00000170683 ENSG00000281680 ENSMUSG00000046431 UniProt P58181 Q8VEW1 RefSeq (mRNA) NM_001003745 NM_146306 RefSeq (protein) NP_001003745 NP_666418 Location (UCSC) Chr 11: 7.94 – 7.94 Mb Chr 7: 108.48 – 108.48 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 10A3 is a protein that in humans is encoded by the OR10A3 gene. ^{[5] [6]}

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[6]

See also

• Olfactory receptor

References

1. ENSG00000170683, ENSG00000281680 GRCh38: Ensembl release 89: ENSG00000273953, ENSG00000170683, ENSG00000281680 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046431 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Parmentier M, Libert F, Schurmans S, Schiffmann S, Lefort A, Eggerickx D, Ledent C, Mollereau C, Gerard C, Perret J, et al. (Mar 1992). "Expression of members of the putative olfactory receptor gene family in mammalian germ cells". Nature. 355 (6359): 453–5. Bibcode:1992Natur.355..453P. doi:10.1038/355453a0. PMID   1370859. S2CID   43926.
6. "Entrez Gene: OR10A3 olfactory receptor, family 10, subfamily A, member 3".

Further reading

• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes" (PDF). Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID   12213199.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.
• Taylor TD, Noguchi H, Totoki Y, et al. (2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification". Nature. 440 (7083): 497–500. Bibcode:2006Natur.440..497T. doi: 10.1038/nature04632 . PMID   16554811.

External links

• OR10A3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.