OR2AG1

OR2AG1
Identifiers
Aliases	OR2AG1 , OR11-79, OR2AG3, olfactory receptor family 2 subfamily AG member 1 (gene/pseudogene), olfactory receptor family 2 subfamily AG member 1
External IDs	MGI: 3030539 HomoloGene: 128075 GeneCards: OR2AG1
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.4 Start 6,783,020 bp [1] End 6,791,558 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 E3 Start 106,471,077 bp [2] End 106,476,098 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cells sural nerve superior frontal gyrus prefrontal cortex temporal lobe amygdala Top expressed in respiratory epithelium olfactory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity olfactory receptor activity G protein-coupled receptor activity protein binding Cellular component plasma membrane membrane integral component of membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 144125 259034 Ensembl ENSG00000279486 ENSMUSG00000109058 UniProt Q9H205 Q9EPF7 RefSeq (mRNA) NM_001004489 NM_147032 RefSeq (protein) NP_001004489 NP_667243 Location (UCSC) Chr 11: 6.78 – 6.79 Mb Chr 7: 106.47 – 106.48 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 2AG1 is a protein that in humans is encoded by the OR2AG1 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

Ligands

Amyl butyrate is a reported ligand for this receptor. ^[6]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000279486 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000109058 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR2AG1 olfactory receptor, family 2, subfamily AG, member 1".
6. Shepard BD, Pluznick JL (May 2016). "How does your kidney smell? Emerging roles for olfactory receptors in renal function". Pediatric Nephrology (Berlin, Germany). 31 (5): 715–23. doi:10.1007/s00467-015-3181-8. PMC   4752438 . PMID   26264790.

Further reading

• Lane RP, Cutforth T, Young J, et al. (2001). "Genomic analysis of orthologous mouse and human olfactory receptor loci". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7390–5. Bibcode:2001PNAS...98.7390L. doi: 10.1073/pnas.131215398 . PMC   34679 . PMID   11416212.
• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID   12213199.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.
• Neuhaus EM, Mashukova A, Zhang W, et al. (2006). "A specific heat shock protein enhances the expression of mammalian olfactory receptor proteins". Chem. Senses. 31 (5): 445–52. doi: 10.1093/chemse/bjj049 . PMID   16565291.
• Mashukova A, Spehr M, Hatt H, Neuhaus EM (2006). "Beta-arrestin2-mediated internalization of mammalian odorant receptors". J. Neurosci. 26 (39): 9902–12. doi:10.1523/JNEUROSCI.2897-06.2006. PMC   6674477 . PMID   17005854.

External links

• OR2AG1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.