OR3A2

OR3A2
Identifiers
Aliases	OR3A2 , OLFRA04, OR17-14, OR17-228, OR228, olfactory receptor family 3 subfamily A member 2
External IDs	MGI: 3030244 HomoloGene: 68262 GeneCards: OR3A2
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17p13.3 Start 3,276,942 bp [1] End 3,386,317 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B5 Start 74,221,107 bp [2] End 74,228,857 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans nucleus accumbens sural nerve caudate nucleus prefrontal cortex putamen hypothalamus substantia nigra lymph node Brodmann area 9 n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity signaling receptor activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process sensory perception of chemical stimulus sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4995 258702 Ensembl ENSG00000221882 ENSMUSG00000063116 UniProt P47893 Q8VFX7 RefSeq (mRNA) NM_002551 NM_146707 RefSeq (protein) NP_002542 NP_666918 Location (UCSC) Chr 17: 3.28 – 3.39 Mb Chr 11: 74.22 – 74.23 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 3A2 is a protein that in humans is encoded by the OR3A2 gene. ^{[5] [6] [7]}

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[7]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000221882 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000063116 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Glusman G, Clifton S, Roe B, Lancet D (Feb 1997). "Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity". Genomics. 37 (2): 147–60. doi:10.1006/geno.1996.0536. PMID   8921386.
6. Glusman G, Sosinsky A, Ben-Asher E, Avidan N, Sonkin D, Bahar A, Rosenthal A, Clifton S, Roe B, Ferraz C, Demaille J, Lancet D (Apr 2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics. 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID   10673334. S2CID   23416814.
7. "Entrez Gene: OR3A2 olfactory receptor, family 3, subfamily A, member 2".

Further reading

• Ben-Arie N, Lancet D, Taylor C, et al. (1994). "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire". Hum. Mol. Genet. 3 (2): 229–35. doi:10.1093/hmg/3.2.229. PMID   8004088.
• Rouquier S, Taviaux S, Trask BJ, et al. (1998). "Distribution of olfactory receptor genes in the human genome". Nat. Genet. 18 (3): 243–50. doi:10.1038/ng0398-243. PMID   9500546. S2CID   31129045.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR3A2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.