OR10A4

OR10A4
Identifiers
Aliases	OR10A4 , JCG5, OR10A4P, olfactory receptor family 10 subfamily A member 4
External IDs	MGI: 109148 HomoloGene: 23241 GeneCards: OR10A4
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.4 Start 6,876,625 bp [1] End 6,877,619 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 E3 Start 106,692,427 bp [2] End 106,699,015 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cells corpus callosum placenta gonad male reproductive system testicle Top expressed in respiratory epithelium olfactory epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell axon guidance G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 283297 18314 Ensembl ENSG00000170782 ENSMUSG00000073897 UniProt Q9H209 Q7TRM9 RefSeq (mRNA) NM_207186 NM_020598 RefSeq (protein) NP_997069 NP_065623 Location (UCSC) Chr 11: 6.88 – 6.88 Mb Chr 7: 106.69 – 106.7 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 10A4 is a protein that in humans is encoded by the OR10A4 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000170782 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000073897 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR10A4 olfactory receptor, family 10, subfamily A, member 4".

Further reading

• Lane RP, Cutforth T, Young J, et al. (2001). "Genomic analysis of orthologous mouse and human olfactory receptor loci". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7390–5. Bibcode:2001PNAS...98.7390L. doi: 10.1073/pnas.131215398 . PMC   34679 . PMID   11416212.
• Gaudin JC, Breuils L, Haertlé T (2002). "New GPCRs from a human lingual cDNA library". Chem. Senses. 26 (9): 1157–66. doi: 10.1093/chemse/26.9.1157 . PMID   11705801.
• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID   12213199.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR10A4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.