OR10J5

OR10J5
Identifiers
Aliases	OR10J5 , OR1-28, olfactory receptor family 10 subfamily J member 5, OLFR16, MOR23
External IDs	MGI: 106648 HomoloGene: 7460 GeneCards: OR10J5
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q23.2 Start 159,535,078 bp [1] End 159,536,007 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 H3 Start 172,777,976 bp [2] End 172,785,924 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in liver Top expressed in spermatid respiratory epithelium olfactory epithelium spermatocyte gland endocrine gland abdominal segment of trunk abdomen Region I of hippocampus proper hippocampus proper More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity neurotransmitter receptor activity G protein-coupled serotonin receptor activity Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane dendrite Biological process sensory perception of smell detection of chemical stimulus involved in sensory perception of smell signal transduction response to stimulus G protein-coupled serotonin receptor signaling pathway G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 127385 18313 Ensembl ENSG00000184155 ENSMUSG00000037924 UniProt Q8NHC4 Q62007 RefSeq (mRNA) NM_001004469 NM_008763 RefSeq (protein) NP_001004469 NP_032789 Location (UCSC) Chr 1: 159.54 – 159.54 Mb Chr 1: 172.78 – 172.79 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 10J5 is a protein that in humans is encoded by the OR10J5 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

Ligands

OR10J5 is a relatively narrowly-tuned receptor, meaning it responds only to a relatively small set of related odorants. ^[6]

Ligands include Lyral, ^[6] an aldehyde with a soft floral scent.

References

1. GRCh38: Ensembl release 89: ENSG00000184155 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037924 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR10J5 olfactory receptor, family 10, subfamily J, member 5".
6. Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD (March 2009). "Odor coding by a Mammalian receptor repertoire". Science Signaling. 2 (60): ra9. doi:10.1126/scisignal.2000016. PMC   2774247 . PMID   19261596.

Further reading

• Gilad Y, Bustamante CD, Lancet D, Pääbo S (2003). "Natural Selection on the Olfactory Receptor Gene Family in Humans and Chimpanzees". Am. J. Hum. Genet. 73 (3): 489–501. doi:10.1086/378132. PMC   1180675 . PMID   12908129.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR10J5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.