OR4C12

OR4C12
Identifiers
Aliases	OR4C12 , OR11-259, olfactory receptor family 4 subfamily C member 12
External IDs	MGI: 3031089; HomoloGene: 82298; GeneCards: OR4C12; OMA:OR4C12 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p11.12 Start 49,981,473 bp [1] End 49,982,535 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 E1 Start 89,642,395 bp [2] End 89,648,204 bp [2]
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity transmembrane signaling receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell detection of chemical stimulus involved in sensory perception of smell detection of chemical stimulus involved in sensory perception signal transduction response to stimulus G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 283093 258979 Ensembl ENSG00000284255 ENSG00000221954 ENSMUSG00000045148 UniProt Q96R67 n/a RefSeq (mRNA) NM_001005270 NM_146977 RefSeq (protein) NP_001005270 n/a Location (UCSC) Chr 11: 49.98 – 49.98 Mb Chr 2: 89.64 – 89.65 Mb PubMed search [3] [4]
Wikidata
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Olfactory receptor 4C12 is a protein that in humans is encoded by the OR4C12 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. ENSG00000221954 GRCh38: Ensembl release 89: ENSG00000284255, ENSG00000221954 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000045148 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR4C12 olfactory receptor, family 4, subfamily C, member 12".

Further reading

• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. CiteSeerX   10.1.1.135.3652 . doi:10.1006/geno.2002.6830. PMID   12213199.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR4C12+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.