OR8A1

OR8A1
Identifiers
Aliases	OR8A1 , OR11-318, OST025, olfactory receptor family 8 subfamily A member 1
External IDs	MGI: 1931271 HomoloGene: 12726 GeneCards: OR8A1
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q24.2 Start 124,566,660 bp [1] End 124,582,942 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 A4 Start 37,620,260 bp [2] End 37,627,546 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon liver corpus callosum placenta endometrium blood prefrontal cortex gonad male reproductive system testicle Top expressed in respiratory epithelium peripheral nervous system olfactory epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity olfactory receptor activity odorant binding Cellular component integral component of membrane plasma membrane membrane Biological process response to stimulus signal transduction sensory perception of smell detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 390275 80706 Ensembl ENSG00000196119 ENSMUSG00000061165 UniProt Q8NGG7 Q8VGE3 RefSeq (mRNA) NM_001005194 NM_030553 RefSeq (protein) NP_001005194 NP_085030 Location (UCSC) Chr 11: 124.57 – 124.58 Mb Chr 9: 37.62 – 37.63 Mb PubMed search [3] [4]
Wikidata
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Olfactory receptor 8A1 is a protein that in humans is encoded by the OR8A1 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000196119 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000061165 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR8A1 olfactory receptor, family 8, subfamily A, member 1".

Further reading

• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID   12213199.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR8A1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.