OR52A5

OR52A5
Identifiers
Aliases	OR52A5 , OR11-33, olfactory receptor family 52 subfamily A member 5
External IDs	MGI: 1341789 HomoloGene: 128070 GeneCards: OR52A5
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.4 Start 5,128,776 bp [1] End 5,138,356 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 E3 Start 103,415,012 bp [2] End 103,420,801 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad male reproductive system testicle Top expressed in respiratory epithelium olfactory epithelium nucleus of brain telencephalic nucleus basal forebrain cerebral hemisphere septal nuclei cerebral cortex hippocampal formation hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 390054 18370 Ensembl ENSG00000171944 ENSMUSG00000058662 UniProt Q9H2C5 E9Q7C5 RefSeq (mRNA) NM_001005160 NM_013621 RefSeq (protein) NP_001005160 NP_038649 Location (UCSC) Chr 11: 5.13 – 5.14 Mb Chr 7: 103.42 – 103.42 Mb PubMed search [3] [4]
Wikidata
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Olfactory receptor 52A5 is a protein that in humans is encoded by the OR52A5 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000171944 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058662 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR52A5 olfactory receptor, family 52, subfamily A, member 5".

Further reading

• Bulger M, Bender MA, van Doorninck JH, et al. (2001). "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14560–5. doi: 10.1073/pnas.97.26.14560 . PMC   18958 . PMID   11121057.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR52A5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.