OR5W2

OR5W2
Identifiers
Aliases	OR5W2 , OR5W2P, OR5W3P, olfactory receptor family 5 subfamily W member 2
External IDs	MGI: 3030985; HomoloGene: 36999; GeneCards: OR5W2; OMA:OR5W2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q12.1 Start 55,913,650 bp [1] End 55,914,582 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 D Start 87,686,206 bp [2] End 87,690,267 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle epithelium of colon monocyte n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity odorant binding olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 390148 258631 Ensembl ENSG00000187612 ENSMUSG00000047039 UniProt Q8NH69 Q8VFQ8 RefSeq (mRNA) NM_001001960 NM_146638 RefSeq (protein) NP_001001960 NP_666849 Location (UCSC) Chr 11: 55.91 – 55.91 Mb Chr 2: 87.69 – 87.69 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 5W2 is a protein in humans that is encoded by the OR5W2 gene. ^[5]

Function

Olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCRs) arising from single coding-exon genes. Olfactory receptors share a seven-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G-protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the human genome. The nomenclature assigned to the olfactory receptor genes and proteins in humans is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000187612 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047039 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR5W2 olfactory receptor, family 5, subfamily W, member 2".

Further reading

• Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, Shmulevich D, Elkon R, Steinfath M, O'Brien JK, Radelof U, Lehrach H, Lancet D, Shamir R (September 2002). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. CiteSeerX   10.1.1.135.3652 . doi:10.1006/geno.2002.6830. PMID   12213199.
• Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR5W2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.