OR52L1

OR52L1
Identifiers
Aliases	OR52L1 , OR11-50, olfactory receptor family 52 subfamily L member 1, olfactory receptor family 52 subfamily L member 1 (gene/pseudogene)
External IDs	MGI: 3030519 HomoloGene: 66455 GeneCards: OR52L1
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.4 Start 5,985,892 bp [1] End 5,986,985 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 E3 Start 104,827,623 bp [2] End 104,835,219 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in fundus body of stomach left ventricle Top expressed in respiratory epithelium olfactory epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 338751 258160 Ensembl ENSG00000183313 ENSMUSG00000047794 UniProt Q8NGH7 n/a RefSeq (mRNA) NM_001005173 NM_001011857 RefSeq (protein) NP_001005173 n/a Location (UCSC) Chr 11: 5.99 – 5.99 Mb Chr 7: 104.83 – 104.84 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 52L1 is a protein that in humans is encoded by the OR52L1 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000183313 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047794 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR52L1 olfactory receptor, family 52, subfamily L, member 1".

Further reading

• Gilad Y, Bustamante CD, Lancet D, Pääbo S (2003). "Natural selection on the olfactory receptor gene family in humans and chimpanzees". Am. J. Hum. Genet. 73 (3): 489–501. doi:10.1086/378132. PMC   1180675 . PMID   12908129.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–2589. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR52L1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.