OR2M3

OR2M3
Identifiers
Aliases	OR2M3 , OR1-54, OR2M3P, OR2M6, OST003, olfactory receptor family 2 subfamily M member 3
External IDs	MGI: 3029998 HomoloGene: 51725 GeneCards: OR2M3
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q44 Start 248,197,265 bp [1] End 248,212,925 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 A3 Start 19,102,854 bp [2] End 19,132,814 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve rectum endometrium renal cortex prefrontal cortex fundus Top expressed in spleen uterus thymus duodenum More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 127062 258443 Ensembl ENSG00000228198 ENSMUSG00000050742 UniProt Q8NG83 Q8VF87 RefSeq (mRNA) NM_001004689 NM_146451 RefSeq (protein) NP_001004689 NP_666662 Location (UCSC) Chr 1: 248.2 – 248.21 Mb Chr 16: 19.1 – 19.13 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 2M3 is a protein that in humans is encoded by the OR2M3 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

OR2M3 has a copper binding pocket. ^[6]

Ligands

• 3-Mercapto-2-methylpentan-1-ol ^[7]

This chemical is associated with characteristic smell of raw onions.

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000228198 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050742 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR2M3 olfactory receptor, family 2, subfamily M, member 3".
6. Haag F, Ahmed L, Reiss K, Block E, Batista VS, Krautwurst D (August 2019). "Copper-mediated thiol potentiation and mutagenesis-guided modeling suggest a highly conserved copper-binding motif in human OR2M3". Cellular and Molecular Life Sciences. 77 (11): 2157–2179. doi: 10.1007/s00018-019-03279-y . PMC   7256108 . PMID   31435697.
7. Noe F, Polster J, Geithe C, Kotthoff M, Schieberle P, Krautwurst D (March 2017). "OR2M3: A Highly Specific and Narrowly Tuned Human Odorant Receptor for the Sensitive Detection of Onion Key Food Odorant 3-Mercapto-2-methylpentan-1-ol". Chemical Senses. 42 (3): 195–210. doi: 10.1093/chemse/bjw118 . PMID   27916748.

Further reading

• Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, et al. (September 2002). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID   12213199.
• Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR2M3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.