OR2W3

OR2W3
Identifiers
Aliases	OR2W3 , OR2W3P, OR2W8P, OST718, olfactory receptor family 2 subfamily W member 3
External IDs	OMIM: 616729 MGI: 3030156 HomoloGene: 19876 GeneCards: OR2W3
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q44 Start 247,895,587 bp [1] End 247,896,531 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B1.3 Start 58,549,608 bp [2] End 58,560,354 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood monocyte spongy bone bone marrow right lobe of thyroid gland left lobe of thyroid gland prefrontal cortex tibial nerve bone marrow cells hypothalamus Top expressed in bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity olfactory receptor activity Cellular component membrane plasma membrane integral component of membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 343171 404346 Ensembl ENSG00000238243 ENSMUSG00000063549 UniProt Q7Z3T1 Q5NCC8 RefSeq (mRNA) NM_001001957 NM_207693 RefSeq (protein) NP_001001957 NP_997576 Location (UCSC) Chr 1: 247.9 – 247.9 Mb Chr 11: 58.55 – 58.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 2W3 is a protein that in humans is encoded by the OR2W3 gene. ^{[5] [6]}

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[6]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000238243 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000063549 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Malnic B, Godfrey PA, Buck LB (Feb 2004). "The human olfactory receptor gene family". Proc Natl Acad Sci U S A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.
6. "Entrez Gene: OR2W3 olfactory receptor, family 2, subfamily W, member 3".

Further reading

• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi: 10.1101/gr.6.9.807 . PMID   8889549.
• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. CiteSeerX   10.1.1.135.3652 . doi:10.1006/geno.2002.6830. PMID   12213199.

External links

• OR2W3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.