OR51B6

OR51B6
Identifiers
Aliases	OR51B6 , HOR5'Beta6, olfactory receptor family 51 subfamily B member 6
External IDs	MGI: 1341910; HomoloGene: 66459; GeneCards: OR51B6; OMA:OR51B6 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.4 Start 5,351,508 bp [1] End 5,352,446 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 E3 Start 103,552,694 bp [2] End 103,557,857 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve stromal cell of endometrium bone marrow cells Top expressed in respiratory epithelium nasal epithelium olfactory epithelium lumbar subsegment of spinal cord lumbar spinal ganglion carotid body stria vascularis submandibular gland thoracic diaphragm nucleus of stria terminalis More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 390058 18365 Ensembl ENSG00000176239 ENSMUSG00000110259 UniProt Q9H340 n/a RefSeq (mRNA) NM_001004750 NM_013616 RefSeq (protein) NP_001004750 n/a Location (UCSC) Chr 11: 5.35 – 5.35 Mb Chr 7: 103.55 – 103.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 51B6 is a protein that in humans is encoded by the OR51B6 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000176239 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000110259 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "OR51B6 olfactory receptor family 51 subfamily B member 6 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-07-27.

Further reading

• Bulger M, van Doorninck JH, Saitoh N, et al. (1999). "Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 5129–34. Bibcode:1999PNAS...96.5129B. doi: 10.1073/pnas.96.9.5129 . PMC   21828 . PMID   10220430.
• Bulger M, Bender MA, van Doorninck JH, et al. (2001). "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14560–5. Bibcode:2000PNAS...9714560B. doi: 10.1073/pnas.97.26.14560 . PMC   18958 . PMID   11121057.

External links

• OR51B6+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.