OR8D4

OR8D4
Identifiers
Aliases	OR8D4 , OR11-275, olfactory receptor family 8 subfamily D member 4
External IDs	MGI: 3030819 HomoloGene: 17416 GeneCards: OR8D4
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q24.1 Start 123,902,167 bp [1] End 123,909,229 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 A5.1 Start 40,037,604 bp [2] End 40,041,480 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas reproductive system reproductive organ gonad male reproductive system testicle Top expressed in respiratory epithelium olfactory epithelium yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity olfactory receptor activity odorant binding Cellular component integral component of membrane plasma membrane membrane Biological process response to stimulus signal transduction sensory perception of smell detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 338662 258854 Ensembl ENSG00000181518 ENSMUSG00000049073 UniProt Q8NGM9 Q8VGB4 RefSeq (mRNA) NM_001005197 NM_146855 RefSeq (protein) NP_001005197 NP_667066 Location (UCSC) Chr 11: 123.9 – 123.91 Mb Chr 9: 40.04 – 40.04 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 8D4 is a protein that in humans is encoded by the OR8D4 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000181518 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000049073 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR8D4 olfactory receptor, family 8, subfamily D, member 4".

Further reading

• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR8D4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.