OR1L8

OR1L8
Identifiers
Aliases	OR1L8 , OR9-24, olfactory receptor family 1 subfamily L member 8
External IDs	MGI: 3030189 HomoloGene: 132326 GeneCards: OR1L8
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q33.2 Start 122,567,117 bp [1] End 122,583,384 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 B Start 36,815,202 bp [2] End 36,818,909 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa Achilles tendon endometrium tibial nerve urinary bladder right coronary artery subcutaneous adipose tissue spleen superior frontal gyrus right lung n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity olfactory receptor activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell detection of chemical stimulus involved in sensory perception of smell signal transduction response to stimulus G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 138881 258618 Ensembl ENSG00000171496 ENSMUSG00000075380 UniProt Q8NGR8 Q8VFP6 RefSeq (mRNA) NM_001004454 NM_146625 RefSeq (protein) NP_001004454 NP_666836 Location (UCSC) Chr 9: 122.57 – 122.58 Mb Chr 2: 36.82 – 36.82 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 1L8 is a protein that in humans is encoded by the OR1L8 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000171496 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000075380 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR1L8 olfactory receptor, family 1, subfamily L, member 8".

Further reading

• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID   12213199.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR1L8+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.