OR8D2

OR8D2
Identifiers
Aliases	OR8D2 , JCG2, olfactory receptor family 8 subfamily D member 2 (gene/pseudogene), olfactory receptor family 8 subfamily D member 2
External IDs	MGI: 3030758 HomoloGene: 128215 GeneCards: OR8D2
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q24.2 Start 124,319,262 bp [1] End 124,320,197 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 A5.1 Start 38,755,745 bp [2] End 38,762,791 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in material anatomical entity anatomical structure multicellular organism organ system reproductive system reproductive organ male reproductive system gonad testicle n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity odorant binding signal transducer activity olfactory receptor activity Cellular component integral component of membrane membrane plasma membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 283160 404322 Ensembl ENSG00000279116 ENSMUSG00000062103 UniProt Q9GZM6 Q7TRB8 RefSeq (mRNA) NM_001002918 NM_207560 RefSeq (protein) NP_001002918 NP_997443 Location (UCSC) Chr 11: 124.32 – 124.32 Mb Chr 9: 38.76 – 38.76 Mb PubMed search [3] [4]
Wikidata
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Olfactory receptor 8D2 is a protein that in humans is encoded by the OR8D2 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000279116 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000062103 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR8D2 olfactory receptor, family 8, subfamily D, member 2".

Further reading

• Gaudin JC, Breuils L, Haertlé T (2002). "New GPCRs from a human lingual cDNA library". Chem. Senses. 26 (9): 1157–66. doi: 10.1093/chemse/26.9.1157 . PMID   11705801.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR8D2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.