OR2AK2

OR2AK2
Identifiers
Aliases	OR2AK2 , OR1-47, OR2AK1P, olfactory receptor family 2 subfamily AK member 2
External IDs	MGI: 3030150 HomoloGene: 133825 GeneCards: OR2AK2
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q44 Start 247,965,233 bp [1] End 247,966,386 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B1.3 Start 58,643,560 bp [2] End 58,650,497 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex nucleus accumbens hypothalamus male reproductive system testicle Top expressed in secondary oocyte hippocampus proper gonad testicle More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 391191 258064 Ensembl ENSG00000187080 ENSMUSG00000107677 UniProt Q8NG84 A0A0N4SVP2 RefSeq (mRNA) NM_001004491 NM_001011818 RefSeq (protein) NP_001004491 NP_001011818 Location (UCSC) Chr 1: 247.97 – 247.97 Mb Chr 11: 58.64 – 58.65 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 2AK2 is a protein that in humans is encoded by the OR2AK2 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000187080 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000107677 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR2AK2 olfactory receptor, family 2, subfamily AK, member 2".

Further reading

• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR2AK2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.