OR8B8

OR8B8
Identifiers
Aliases	OR8B8 , TPCR85, olfactory receptor family 8 subfamily B member 8
External IDs	MGI: 2177528 HomoloGene: 56568 GeneCards: OR8B8
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q24.2 Start 124,437,445 bp [1] End 124,445,696 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 A4 Start 37,808,020 bp [2] End 37,814,815 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in atrium Top expressed in epithelium organ system sensory system respiratory epithelium sensory organ structure with developmental contribution from neural crest peripheral nervous system olfactory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity odorant binding olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26493 258310 Ensembl ENSG00000197125 ENSMUSG00000066748 UniProt Q15620 Q60882 RefSeq (mRNA) NM_012378 NM_146313 RefSeq (protein) NP_036510 NP_666425 Location (UCSC) Chr 11: 124.44 – 124.45 Mb Chr 9: 37.81 – 37.81 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 8B8 is a protein that in humans is encoded by the OR8B8 gene. ^{[5] [6]}

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[6]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000197125 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000066748 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Vanderhaeghen P, Schurmans S, Vassart G, Parmentier M (Apr 1997). "Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species". Genomics. 39 (3): 239–46. doi:10.1006/geno.1996.4490. PMID   9119360.
6. "Entrez Gene: OR8B8 olfactory receptor, family 8, subfamily B, member 8".

Further reading

• Gaudin JC, Breuils L, Haertlé T (2002). "New GPCRs from a human lingual cDNA library". Chem. Senses. 26 (9): 1157–66. doi: 10.1093/chemse/26.9.1157 . PMID   11705801.
• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes" (PDF). Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID   12213199.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR8B8+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.