OR51I2

OR51I2
Identifiers
Aliases	OR51I2 , OR11-38, olfactory receptor family 51 subfamily I member 2
External IDs	MGI: 3030475 HomoloGene: 17489 GeneCards: OR51I2
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.4 Start 5,449,323 bp [1] End 5,456,518 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 E3 Start 103,684,652 bp [2] End 103,691,279 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibialis anterior muscle pancreatic ductal cell deltoid muscle lower lobe of lung Top expressed in respiratory epithelium olfactory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 390064 259075 Ensembl ENSG00000187918 ENSMUSG00000073932 UniProt Q9H344 Q8VGX6 RefSeq (mRNA) NM_001004754 NM_147072 RefSeq (protein) NP_001004754 NP_667283 Location (UCSC) Chr 11: 5.45 – 5.46 Mb Chr 7: 103.68 – 103.69 Mb PubMed search [3] [4]
Wikidata
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Olfactory receptor 51I2 is a protein that in humans is encoded by the OR51I2 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000187918 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000073932 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR51I2 olfactory receptor, family 51, subfamily I, member 2".

Further reading

• Bulger M, van Doorninck JH, Saitoh N, et al. (1999). "Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 5129–34. Bibcode:1999PNAS...96.5129B. doi: 10.1073/pnas.96.9.5129 . PMC   21828 . PMID   10220430.
• Bulger M, Bender MA, van Doorninck JH, et al. (2001). "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14560–5. doi: 10.1073/pnas.97.26.14560 . PMC   18958 . PMID   11121057.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR51I2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.