OR2C1

OR2C1
Identifiers
Aliases	OR2C1 , OLFmf3, OR2C2P, olfactory receptor family 2 subfamily C member 1
External IDs	MGI: 106182 HomoloGene: 7459 GeneCards: OR2C1
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p13.3 Start 3,355,889 bp [1] End 3,357,306 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 A1 Start 3,648,742 bp [2] End 3,662,611 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibialis anterior muscle deltoid muscle fallopian tube right uterine tube lymph node islet of Langerhans spinal cord endometrium Brodmann area 9 kidney Top expressed in Jacobson's organ respiratory epithelium olfactory epithelium skin of abdomen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity olfactory receptor activity odorant binding Cellular component integral component of membrane plasma membrane membrane cell cortex Biological process signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell sensory perception of smell G protein-coupled receptor signaling pathway detection of chemical stimulus involved in sensory perception Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4993 18312 Ensembl ENSG00000168158 ENSMUSG00000059043 UniProt O95371 P23275 RefSeq (mRNA) NM_012368 NM_008762 RefSeq (protein) NP_036500 NP_032788 Location (UCSC) Chr 16: 3.36 – 3.36 Mb Chr 16: 3.65 – 3.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 2C1 is a protein that in humans is encoded by the OR2C1 gene. ^{[5] [6]}

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[6]

Ligands

• Octanethiol ^[7]
• Nonanethiol ^[7]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000168158 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000059043 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Centola M, Chen X, Sood R, Deng Z, Aksentijevich I, Blake T, Ricke DO, Chen X, Wood G, Zaks N, Richards N, Krizman D, Mansfield E, Apostolou S, Liu J, Shafran N, Vedula A, Hamon M, Cercek A, Kahan T, Gumucio D, Callen DF, Richards RI, Moyzis RK, Doggett NA, Collins FS, Liu PP, Fischel-Ghodsian N, Kastner DL (Jan 1999). "Construction of an ∼700-kb Transcript Map Around the Familial Mediterranean Fever Locus on Human Chromosome 16p13.3". Genome Res. 8 (11): 1172–91. doi:10.1101/gr.8.11.1172. PMC   310791 . PMID   9847080.
6. "Entrez Gene: OR2C1 olfactory receptor, family 2, subfamily C, member 1".
7. Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD (March 2009). "Odor coding by a Mammalian receptor repertoire". Science Signaling. 2 (60): ra9. doi:10.1126/scisignal.2000016. PMC   2774247 . PMID   19261596.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.

External links

• OR2C1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.