OR4F4

OR4F4
Identifiers
Aliases	OR4F4 , OLA-7501, OR4F18, olfactory receptor family 4 subfamily F member 4
External IDs	HomoloGene: 128250 GeneCards: OR4F4
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q26.3 Start 101,922,042 bp [1] End 101,923,113 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve fundus blood muscle of leg heart esophagus adrenal gland n/a More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity transmembrane signaling receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell detection of chemical stimulus involved in sensory perception of smell detection of chemical stimulus involved in sensory perception signal transduction response to stimulus G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26682 n/a Ensembl ENSG00000177693 n/a UniProt Q96R69 n/a RefSeq (mRNA) NM_001004195 n/a RefSeq (protein) NP_001004195 n/a Location (UCSC) Chr 15: 101.92 – 101.92 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Olfactory receptor 4F4 is a protein that in humans is encoded by the OR4F4 gene. ^[3]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[3]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000177693 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: OR4F4 olfactory receptor, family 4, subfamily F, member 4".

Further reading

• Trask BJ, Friedman C, Martin-Gallardo A, et al. (1998). "Members of the olfactory receptor gene family are contained in large blocks of DNA duplicated polymorphically near the ends of human chromosomes". Hum. Mol. Genet. 7 (1): 13–26. doi: 10.1093/hmg/7.1.13 . PMID   9384599.
• Mefford HC, Linardopoulou E, Coil D, et al. (2002). "Comparative sequencing of a multicopy subtelomeric region containing olfactory receptor genes reveals multiple interactions between non-homologous chromosomes". Hum. Mol. Genet. 10 (21): 2363–72. doi:10.1093/hmg/10.21.2363. PMID   11689483.
• Linardopoulou E, Mefford HC, Nguyen O, et al. (2002). "Transcriptional activity of multiple copies of a subtelomerically located olfactory receptor gene that is polymorphic in number and location". Hum. Mol. Genet. 10 (21): 2373–83. doi: 10.1093/hmg/10.21.2373 . PMID   11689484.
• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes" (PDF). Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID   12213199.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR4F4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.