OR2A12

OR2A12
Identifiers
Aliases	OR2A12 , OR2A12P, OR2A16P, olfactory receptor family 2 subfamily A member 12
External IDs	MGI: 3030280 HomoloGene: 17179 GeneCards: OR2A12
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q35 Start 144,086,278 bp [1] End 144,098,953 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 B2.1 Start 42,898,311 bp [2] End 42,908,075 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in reproductive system reproductive organ gonad male reproductive system testicle n/a More reference expression data BioGPS n/a
Gene ontology Molecular function signal transducer activity olfactory receptor activity G protein-coupled receptor activity Cellular component plasma membrane membrane integral component of membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 346525 258292 Ensembl ENSG00000221858 ENSG00000284949 ENSMUSG00000073111 UniProt Q8NGT7 Q8VEV0 RefSeq (mRNA) NM_001004135 NM_146295 RefSeq (protein) NP_001004135 NP_666407 Location (UCSC) Chr 7: 144.09 – 144.1 Mb Chr 6: 42.9 – 42.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 2A12 is a protein that in humans is encoded by the OR2A12 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. ENSG00000284949 GRCh38: Ensembl release 89: ENSG00000221858, ENSG00000284949 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000073111 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR2A12 olfactory receptor, family 2, subfamily A, member 12".

Further reading

• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. CiteSeerX   10.1.1.145.6233 . doi:10.1006/geno.2002.6830. PMID   12213199.
• Gilad Y, Lancet D (2003). "Population differences in the human functional olfactory repertoire". Mol. Biol. Evol. 20 (3): 307–14. doi: 10.1093/molbev/msg013 . PMID   12644552.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC   2882961 . PMID   12690205.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR2A12+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.