OR6C4

OR6C4
Identifiers
Aliases	OR6C4 , OR12-10, olfactory receptor family 6 subfamily C member 4
External IDs	HomoloGene: 79371 GeneCards: OR6C4
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q13.2 Start 55,549,602 bp [1] End 55,555,832 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gallbladder lobe of thyroid gland left lobe of thyroid gland respiratory system intestine circulatory system colon human thorax transverse colon esophagus n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell detection of chemical stimulus involved in sensory perception of smell signal transduction response to stimulus G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 341418 n/a Ensembl ENSG00000179626 n/a UniProt Q8NGE1 n/a RefSeq (mRNA) NM_001005494 NM_001385975 n/a RefSeq (protein) NP_001005494 n/a Location (UCSC) Chr 12: 55.55 – 55.56 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Olfactory receptor 6C4 is a protein that in humans is encoded by the OR6C4 gene. ^[3]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[3]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000179626 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: OR6C4 olfactory receptor, family 6, subfamily C, member 4".

Further reading

• Lauzurica P, Bragado R, López D, Galocha B, López De Castro JA (1992). "Asymmetric selection of T cell antigen receptor alpha- and beta-chains in HLA-B27 alloreactivity". J. Immunol. 148 (11): 3624–30. doi:10.4049/jimmunol.148.11.3624. PMID   1316921.
• Youngblood K, Fruchter L, Ding G, Lopez J, Bonagura V, Davidson A (1994). "Rheumatoid factors from the peripheral blood of two patients with rheumatoid arthritis are genetically heterogeneous and somatically mutated". J. Clin. Invest. 93 (2): 852–61. doi:10.1172/JCI117040. PMC   293948 . PMID   7509350.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR6C4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.