OR10K2

OR10K2
Identifiers
Aliases	OR10K2 , OR1-4, olfactory receptor family 10 subfamily K member 2
External IDs	MGI: 3030204 HomoloGene: 74037 GeneCards: OR10K2
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q23.1 Start 158,418,210 bp [1] End 158,426,237 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 C2 Start 84,262,409 bp [2] End 84,271,856 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in kidney muscle of leg blood multicellular organism n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity transmembrane signaling receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell detection of chemical stimulus involved in sensory perception of smell detection of chemical stimulus involved in sensory perception signal transduction response to stimulus G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 391107 258267 Ensembl ENSG00000180708 ENSMUSG00000047286 UniProt Q6IF99 E9Q848 RefSeq (mRNA) NM_001004476 NM_146270 RefSeq (protein) NP_001004476 NP_666382 Location (UCSC) Chr 1: 158.42 – 158.43 Mb Chr 8: 84.26 – 84.27 Mb PubMed search [3] [4]
Wikidata
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Olfactory receptor 10K2 is a protein that in humans is encoded by the OR10K2 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000180708 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047286 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR10K2 olfactory receptor, family 10, subfamily K, member 2".

Further reading

• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.

External links

• OR10K2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.