OR4A15

OR4A15
Identifiers
Aliases	OR4A15 , OR11-118, olfactory receptor family 4 subfamily A member 15
External IDs	MGI: 3031068 HomoloGene: 128156 GeneCards: OR4A15
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q11 Start 55,367,974 bp [1] End 55,368,918 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 E1 Start 89,190,357 bp [2] End 89,195,209 bp [2]
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity transmembrane signaling receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell detection of chemical stimulus involved in sensory perception of smell detection of chemical stimulus involved in sensory perception signal transduction response to stimulus G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81328 258975 Ensembl ENSG00000181958 ENSMUSG00000075090 UniProt Q8NGL6 A2AVK5 RefSeq (mRNA) NM_001005275 NM_146973 RefSeq (protein) NP_001005275 NP_667184 Location (UCSC) Chr 11: 55.37 – 55.37 Mb Chr 2: 89.19 – 89.2 Mb PubMed search [3] [4]
Wikidata
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Olfactory receptor 4A15 is a protein that in humans is encoded by the OR4A15 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000181958 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000075090 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR4A15 olfactory receptor, family 4, subfamily A, member 15".

Further reading

• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID   12213199.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR4A15+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.