OR1A2

OR1A2
Identifiers
Aliases	OR1A2 , OR17-6, olfactory receptor family 1 subfamily A member 2
External IDs	OMIM: 618047 GeneCards: OR1A2
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17p13.3 Start 3,197,519 bp [1] End 3,198,448 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood multicellular organism n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process positive regulation of cytokinesis sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26189 n/a Ensembl ENSG00000172150 n/a UniProt Q9Y585 n/a RefSeq (mRNA) NM_012352 n/a RefSeq (protein) NP_036484 n/a Location (UCSC) Chr 17: 3.2 – 3.2 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Olfactory receptor 1A2 is a protein that in humans is encoded by the OR1A2 gene. ^{[3] [4]}

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[4]

Ligands

The known ligands of OR1A2 are near-identical to those of OR1A1. ^[5] Examples of known ligands, most of which have citrus or fruity smells: ^{[5] [6]}

• (S)-(−)-citronellal
• Helional
• Heptanal
• Octanal
• Nonanal (weaker than heptanal/octanal ^[5] )
• Hydroxycitronellal
• Citral
• (S)-(−)-Citronellol (in contrast to OR1A1 only this enantiomer is effective; weaker than citronellal ^[5] )

See also

• Olfactory receptor

Notes

1. GRCh38: Ensembl release 89: ENSG00000172150 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Glusman G, Sosinsky A, Ben-Asher E, Avidan N, Sonkin D, Bahar A, Rosenthal A, Clifton S, Roe B, Ferraz C, Demaille J, Lancet D (Apr 2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics. 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID   10673334. S2CID   23416814.
4. "Entrez Gene: OR1A2 olfactory receptor, family 1, subfamily A, member 2".
5. Schmiedeberg K, Shirokova E, Weber HP, Schilling B, Meyerhof W, Krautwurst D (September 2007). "Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2". Journal of Structural Biology. 159 (3): 400–12. doi:10.1016/j.jsb.2007.04.013. PMID   17601748.
6. Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, Kristiansen K, et al. (2014). "Identification of odorant-receptor interactions by global mapping of the human odorome". PLOS ONE. 9 (4): e93037. Bibcode:2014PLoSO...993037A. doi: 10.1371/journal.pone.0093037 . PMC   3973694 . PMID   24695519.

References

• This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Further reading

• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID   12213199.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.

External links

• OR1A2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)