OR1A2

Last updated
OR1A2
Identifiers
Aliases OR1A2 , OR17-6, olfactory receptor family 1 subfamily A member 2
External IDs OMIM: 618047; MGI: 3030237; GeneCards: OR1A2; OMA:OR1A2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012352

NM_207622

RefSeq (protein)

NP_036484

NP_997505

Location (UCSC) Chr 17: 3.2 – 3.2 Mb Chr 11: 74.08 – 74.09 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 1A2 is a protein that in humans is encoded by the OR1A2 gene. [5] [6]

Contents

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [6]

Ligands

The known ligands of OR1A2 are near-identical to those of OR1A1. [7] Examples of known ligands, most of which have citrus or fruity smells: [7] [8]

See also

Notes

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000172150 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000070378 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Glusman G, Sosinsky A, Ben-Asher E, Avidan N, Sonkin D, Bahar A, Rosenthal A, Clifton S, Roe B, Ferraz C, Demaille J, Lancet D (Apr 2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics. 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID   10673334. S2CID   23416814.
  6. 1 2 "Entrez Gene: OR1A2 olfactory receptor, family 1, subfamily A, member 2".
  7. 1 2 3 4 Schmiedeberg K, Shirokova E, Weber HP, Schilling B, Meyerhof W, Krautwurst D (September 2007). "Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2". Journal of Structural Biology. 159 (3): 400–12. doi:10.1016/j.jsb.2007.04.013. PMID   17601748.
  8. Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, Kristiansen K, et al. (2014). "Identification of odorant-receptor interactions by global mapping of the human odorome". PLOS ONE. 9 (4): e93037. Bibcode:2014PLoSO...993037A. doi: 10.1371/journal.pone.0093037 . PMC   3973694 . PMID   24695519.

References

Further reading