OR2T11

OR2T11
Identifiers
Aliases	OR2T11 , OR2T11Q, olfactory receptor family 2 subfamily T member 11 (gene/pseudogene), olfactory receptor family 2 subfamily T member 11
External IDs	HomoloGene: 84585 GeneCards: OR2T11
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q44 Start 248,623,557 bp [1] End 248,635,091 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in kidney kidney n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity olfactory receptor activity G protein-coupled receptor activity Cellular component plasma membrane membrane integral component of membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 127077 n/a Ensembl ENSG00000279301 n/a UniProt Q8NH01 n/a RefSeq (mRNA) NM_001001964 n/a RefSeq (protein) NP_001001964 n/a Location (UCSC) Chr 1: 248.62 – 248.64 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Olfactory receptor 2T11 is a protein that in humans is encoded by the OR2T11 gene. ^[3]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitters and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[3]

Ligands

• tert-Butylthiol (the response is enhanced by the presence of ionic copper). ^[4]
• Ethanethiol (the response is enhanced by the presence of ionic copper). ^[4]
• 2-Propenethiol (allyl mercaptan) (the response is enhanced by the presence of ionic copper). ^[4]
• Thietane (the response is enhanced by the presence of ionic copper). ^[4]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000279301 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: OR2T11 olfactory receptor, family 2, subfamily T, member 11".
4. Li, S.; et al. (2016). "Smelling Sulfur: Copper and Silver Regulate the Response of Human Odorant Receptor OR2T11 to Low-Molecular-Weight Thiols". J. Am. Chem. Soc. 138 (40): 13281–13288. doi:10.1021/jacs.6b06983. PMID   27659093.

Further reading

• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR2T11+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.