OR5M8

OR5M8
Identifiers
Aliases	OR5M8 , OR11-194, olfactory receptor family 5 subfamily M member 8
External IDs	MGI: 3030865 HomoloGene: 73973 GeneCards: OR5M8
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q12.1 Start 56,490,435 bp [1] End 56,491,370 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 D Start 85,820,648 bp [2] End 85,824,048 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in organ system thoracic aorta ascending aorta reproductive system reproductive organ gonad male reproductive system testicle n/a More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity odorant binding olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 219484 257916 Ensembl ENSG00000181371 ENSMUSG00000043267 UniProt Q8NGP6 Q7TR87 RefSeq (mRNA) NM_001005282 NM_001011759 RefSeq (protein) NP_001005282 NP_001011759 Location (UCSC) Chr 11: 56.49 – 56.49 Mb Chr 2: 85.82 – 85.82 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 5M8 is a protein that in humans is encoded by the OR5M8 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000181371 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043267 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR5M8 olfactory receptor, family 5, subfamily M, member 8".

Further reading

• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes" (PDF). Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID   12213199.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR5M8+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.