OR6F1

OR6F1
Identifiers
Aliases	OR6F1 , OR1-34, OR1-38, OST731, olfactory receptor family 6 subfamily F member 1
External IDs	MGI: 3030142 HomoloGene: 27225 GeneCards: OR6F1
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q44 Start 247,711,436 bp [1] End 247,716,646 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 D3 Start 85,967,426 bp [2] End 85,974,838 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle muscle of leg multicellular organism gastrocnemius muscle Top expressed in respiratory epithelium peripheral nervous system olfactory epithelium testicle spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell detection of chemical stimulus involved in sensory perception of smell signal transduction response to stimulus G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 343169 258614 Ensembl ENSG00000169214 ENSMUSG00000054498 UniProt Q8NGZ6 Q8VFP2 RefSeq (mRNA) NM_001005286 NM_146621 RefSeq (protein) NP_001005286 NP_666832 Location (UCSC) Chr 1: 247.71 – 247.72 Mb Chr 7: 85.97 – 85.97 Mb PubMed search [3] [4]
Wikidata
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Olfactory receptor 6F1 is a protein that in humans is encoded by the OR6F1 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000169214 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000054498 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR6F1 olfactory receptor, family 6, subfamily F, member 1".

Further reading

• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID   12213199.
• Gilad Y, Bustamante CD, Lancet D, Pääbo S (2003). "Natural Selection on the Olfactory Receptor Gene Family in Humans and Chimpanzees". Am. J. Hum. Genet. 73 (3): 489–501. doi:10.1086/378132. PMC   1180675 . PMID   12908129.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR6F1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.