OR11H4

OR11H4
Identifiers
Aliases	OR11H4 , OR14-36, olfactory receptor family 11 subfamily H member 4
External IDs	MGI: 3030583; HomoloGene: 10652; GeneCards: OR11H4; OMA:OR11H4 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q11.2 Start 20,239,286 bp [1] End 20,244,349 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 C1 Start 50,973,628 bp [2] End 50,982,551 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh superior frontal gyrus endometrium caudate nucleus Top expressed in embryo More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity G protein-coupled serotonin receptor activity neurotransmitter receptor activity Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane dendrite Biological process sensory perception of smell detection of chemical stimulus involved in sensory perception of smell signal transduction response to stimulus G protein-coupled serotonin receptor signaling pathway G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 390442 56858 Ensembl ENSG00000176198 ENSMUSG00000059069 UniProt Q8NGC9 E9Q438 RefSeq (mRNA) NM_001004479 NM_020288 RefSeq (protein) NP_001004479 NP_064684 Location (UCSC) Chr 14: 20.24 – 20.24 Mb Chr 14: 50.97 – 50.98 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 11H4 is a protein that in humans is encoded by the OR11H4 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

Ligands

• Isovaleric acid ^[6]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000176198 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000059069 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR11H4 olfactory receptor, family 11, subfamily H, member 4".
6. Menashe I, Abaffy T, Hasin Y, Goshen S, Yahalom V, Luetje CW, Lancet D (October 2007). "Genetic elucidation of human hyperosmia to isovaleric acid". PLOS Biology. 5 (11): e284. doi: 10.1371/journal.pbio.0050284 . PMC   2043052 . PMID   17973576.

Further reading

• Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR11H4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.