OR5AN1

OR5AN1
Identifiers
Aliases	OR5AN1 , OR11-244, olfactory receptor family 5 subfamily AN member 1
External IDs	OMIM: 615702; MGI: 3031268; HomoloGene: 45029; GeneCards: OR5AN1; OMA:OR5AN1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q12.1 Start 59,358,895 bp [1] End 59,371,714 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19|19 A Start 12,257,218 bp [2] End 12,262,990 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity odorant binding olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway detection of chemical stimulus involved in sensory perception Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 390195 258680 Ensembl ENSG00000176495 ENSMUSG00000095640 UniProt Q8NGI8 n/a RefSeq (mRNA) NM_001004729 NM_146685 RefSeq (protein) NP_001004729 n/a Location (UCSC) Chr 11: 59.36 – 59.37 Mb Chr 19: 12.26 – 12.26 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 5AN1 is a protein that in humans is encoded by the OR5AN1 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

Ligands

• Civetone
• Muscone ^[6]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000176495 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000095640 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR5AN1 olfactory receptor, family 5, subfamily AN, member 1".
6. Ahmed, L., et al. (2018). "Molecular Mechanism of Activation of Human Musk Receptors OR5AN1 and OR1A1 by (R)-Muscone and Diverse Other Musk-smelling Compounds". Proc. Natl. Acad. Sci. USA . 115 (17): E3950 –E3958. Bibcode:2018PNAS..115E3950A. doi: 10.1073/pnas.1713026115 . PMC   5924878 . PMID   29632183.

Further reading

• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR5AN1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.