OR9A2

OR9A2
Identifiers
Aliases	OR9A2 , olfactory receptor family 9 subfamily A member 2
External IDs	MGI: 3030293 HomoloGene: 83448 GeneCards: OR9A2
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q34 Start 143,026,200 bp [1] End 143,027,132 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 B2.1 Start 41,745,704 bp [2] End 41,752,111 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum substantia nigra prefrontal cortex hippocampus proper placenta temporal lobe amygdala caudate nucleus hypothalamus left coronary artery n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function olfactory receptor activity signal transducer activity G protein-coupled receptor activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell detection of chemical stimulus involved in sensory perception of smell signal transduction response to stimulus G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 135924 258569 Ensembl ENSG00000273914 ENSG00000179468 ENSMUSG00000045479 UniProt Q8NGT5 Q924H8 RefSeq (mRNA) NM_001001658 NM_146576 RefSeq (protein) NP_001001658 NP_666787 Location (UCSC) Chr 7: 143.03 – 143.03 Mb Chr 6: 41.75 – 41.75 Mb PubMed search [3] [4]
Wikidata
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Olfactory receptor 9A2 is a protein that in humans is encoded by the OR9A2 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. ENSG00000179468 GRCh38: Ensembl release 89: ENSG00000273914, ENSG00000179468 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000045479 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR9A2 olfactory receptor, family 9, subfamily A, member 2".

Further reading

• Gilad Y, Bustamante CD, Lancet D, Pääbo S (2003). "Natural selection on the olfactory receptor gene family in humans and chimpanzees". Am. J. Hum. Genet. 73 (3): 489–501. doi:10.1086/378132. PMC   1180675 . PMID   12908129.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR9A2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.