OR4C6

OR4C6
Identifiers
Aliases	OR4C6 , OR11-138, olfactory receptor family 4 subfamily C member 6
External IDs	MGI: 3031064 HomoloGene: 81570 GeneCards: OR4C6
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q11 Start 55,662,201 bp [1] End 55,666,195 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 E1 Start 89,126,695 bp [2] End 89,127,612 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus lymph node prostate Top expressed in respiratory epithelium sensory system sensory organ olfactory epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity transmembrane signaling receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell detection of chemical stimulus involved in sensory perception of smell detection of chemical stimulus involved in sensory perception signal transduction response to stimulus G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 219432 258785 Ensembl ENSG00000181903 ENSMUSG00000075094 UniProt Q8NH72 Q8VG58 RefSeq (mRNA) NM_001004704 NM_146789 RefSeq (protein) NP_001004704 NP_667000 Location (UCSC) Chr 11: 55.66 – 55.67 Mb Chr 2: 89.13 – 89.13 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 4C6 is a protein that in humans is encoded by the OR4C6 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000181903 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000075094 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR4C6 olfactory receptor, family 4, subfamily C, member 6".

Further reading

• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR4C6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.