OR4C3

OR4C3
Identifiers
Aliases	OR4C3 , OR11-98, olfactory receptor family 4 subfamily C member 3
External IDs	MGI: 2177523 HomoloGene: 41379 GeneCards: OR4C3
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p11.2 Start 48,324,920 bp [1] End 48,325,955 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 E1 Start 89,879,724 bp [2] End 89,893,938 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal cortex Top expressed in respiratory epithelium olfactory epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity transmembrane signaling receptor activity signal transducer activity Cellular component membrane plasma membrane integral component of membrane Biological process sensory perception of smell detection of chemical stimulus involved in sensory perception of smell detection of chemical stimulus involved in sensory perception signal transduction response to stimulus G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 256144 57272 Ensembl ENSG00000176547 ENSMUSG00000075068 UniProt Q8NH37 Q60878 RefSeq (mRNA) NM_001004702 NM_020515 RefSeq (protein) NP_001004702 NP_065261 Location (UCSC) Chr 11: 48.32 – 48.33 Mb Chr 2: 89.88 – 89.89 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 4C3 is a protein that in humans is encoded by the OR4C3 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000176547 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000075068 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR4C3 olfactory receptor, family 4, subfamily C, member 3".

Further reading

• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR4C3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.