OR1A1

OR1A1
Identifiers
Aliases	OR1A1 , OR17-7, olfactory receptor family 1 subfamily A member 1, olfactory receptor family 1 subfamily A member 1 (gene/pseudogene)
External IDs	OMIM: 618046; MGI: 1333770; HomoloGene: 8219; GeneCards: OR1A1; OMA:OR1A1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17p13.3 Start 3,207,539 bp [1] End 3,218,896 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B5 Start 74,096,490 bp [2] End 74,102,205 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity olfactory receptor activity G protein-coupled receptor activity Cellular component plasma membrane membrane integral component of membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8383 258706 Ensembl ENSG00000172146 ENSMUSG00000070377 UniProt Q9P1Q5 n/a RefSeq (mRNA) NM_014565 NM_001386104 NM_146711 RefSeq (protein) NP_055380 n/a Location (UCSC) Chr 17: 3.21 – 3.22 Mb Chr 11: 74.1 – 74.1 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 1A1 is a protein that in humans is encoded by the OR1A1 gene. ^{[5] [6]}

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. ^[6]

Ligands

OR1A1 is relatively broadly tuned, meaning it responds to a relatively wide variety of different odor molecules. ^{[7] [8]} Examples of known ligands, most of which have citrus or fruity smells: ^{[9] [10]}

• (S)-(−)-citronellal
• Helional
• Heptanal
• Octanal
• Nonanal (weaker than heptanal/octanal ^[9] )
• Hydroxycitronellal
• Citral
• Citronellol (both enantiomers, weaker than citronellal ^[9] )
• Dihydrojasmone ^[7]
• Thiols ^[8]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000172146 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000070377 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Glusman G, Sosinsky A, Ben-Asher E, Avidan N, Sonkin D, Bahar A, et al. (January 2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics. 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID   10673334. S2CID   23416814.
6. "Entrez Gene: OR1A1 olfactory receptor, family 1, subfamily A, member 1".
7. Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD (March 2009). "Odor coding by a Mammalian receptor repertoire". Science Signaling. 2 (60): ra9. doi:10.1126/scisignal.2000016. PMC   2774247 . PMID   19261596.
8. Block E, Batista VS, Matsunami H, Zhuang H, Ahmed L (May 2017). "The role of metals in mammalian olfaction of low molecular weight organosulfur compounds". Natural Product Reports. 34 (5): 529–557. doi:10.1039/c7np00016b. PMC   5542778 . PMID   28471462.
9. Schmiedeberg K, Shirokova E, Weber HP, Schilling B, Meyerhof W, Krautwurst D (September 2007). "Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2". Journal of Structural Biology. 159 (3): 400–12. doi:10.1016/j.jsb.2007.04.013. PMID   17601748.
10. Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, Kristiansen K, et al. (2014). "Identification of odorant-receptor interactions by global mapping of the human odorome". PLOS ONE. 9 (4): e93037. Bibcode:2014PLoSO...993037A. doi: 10.1371/journal.pone.0093037 . PMC   3973694 . PMID   24695519.

Further reading

• Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, et al. (September 2002). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. CiteSeerX   10.1.1.135.3652 . doi:10.1006/geno.2002.6830. PMID   12213199.
• Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR1A1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.