OR1A1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | OR1A1 , OR17-7, olfactory receptor family 1 subfamily A member 1, olfactory receptor family 1 subfamily A member 1 (gene/pseudogene) | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 618046; MGI: 1333770; HomoloGene: 8219; GeneCards: OR1A1; OMA:OR1A1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Olfactory receptor 1A1 is a protein that in humans is encoded by the OR1A1 gene. [5] [6]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [6]
OR1A1 is relatively broadly tuned, meaning it responds to a relatively wide variety of different odor molecules. [7] [8] Examples of known ligands, most of which have citrus or fruity smells: [9] [10]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.