OR4F6

OR4F6
Identifiers
Aliases	OR4F6 , OR15-15, OR4F12, olfactory receptor family 4 subfamily F member 6
External IDs	MGI: 3031144; HomoloGene: 74053; GeneCards: OR4F6; OMA:OR4F6 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q26.3 Start 101,803,509 bp [1] End 101,806,887 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 E3 Start 111,834,919 bp [2] End 111,843,053 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stomach prefrontal cortex brain substantia nigra hippocampus proper cerebral cortex multicellular organism Top expressed in bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity transmembrane signaling receptor activity signal transducer activity Cellular component membrane integral component of membrane plasma membrane Biological process sensory perception of smell detection of chemical stimulus involved in sensory perception of smell detection of chemical stimulus involved in sensory perception signal transduction response to stimulus G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 390648 258441 Ensembl ENSG00000184140 ENSMUSG00000108827 UniProt Q8NGB9 Q8VF85 RefSeq (mRNA) NM_001005326 NM_146449 RefSeq (protein) NP_001005326 NP_666660 Location (UCSC) Chr 15: 101.8 – 101.81 Mb Chr 2: 111.83 – 111.84 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 4F6 is a protein that in humans is encoded by the OR4F6 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000184140 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000108827 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR4F6 olfactory receptor, family 4, subfamily F, member 6".

Further reading

• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR4F6+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.