OR2K2

OR2K2
Identifiers
Aliases	OR2K2 , HSHTPCRH06, HTPCRH06, OR2AN1P, OR2AR1P, olfactory receptor family 2 subfamily K member 2
External IDs	MGI: 3030101 HomoloGene: 17436 GeneCards: OR2K2
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q31.3 Start 111,327,229 bp [1] End 111,330,224 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 B3 Start 58,782,704 bp [2] End 58,787,716 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in substantia nigra gastrocnemius muscle tibial nerve hippocampus proper hypothalamus putamen Brodmann area 9 amygdala left ventricle prefrontal cortex Top expressed in uterus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26248 258922 Ensembl ENSG00000171133 ENSMUSG00000043385 UniProt Q8NGT1 A2AM35 RefSeq (mRNA) NM_205859 NM_146920 RefSeq (protein) NP_995581 NP_667131 Location (UCSC) Chr 9: 111.33 – 111.33 Mb Chr 4: 58.78 – 58.79 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 2K2 is a protein that in humans is encoded by the OR2K2 gene. ^{[5] [6] [7]}

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[7]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000171133 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043385 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Parmentier M, Libert F, Schurmans S, Schiffmann S, Lefort A, Eggerickx D, Ledent C, Mollereau C, Gerard C, Perret J, et al. (Mar 1992). "Expression of members of the putative olfactory receptor gene family in mammalian germ cells". Nature. 355 (6359): 453–5. Bibcode:1992Natur.355..453P. doi:10.1038/355453a0. PMID   1370859. S2CID   43926.
6. Aloni R, Olender T, Lancet D (Jan 2007). "Ancient genomic architecture for mammalian olfactory receptor clusters". Genome Biol. 7 (10): R88. doi: 10.1186/gb-2006-7-10-r88 . PMC   1794568 . PMID   17010214.
7. "Entrez Gene: OR2K2 olfactory receptor, family 2, subfamily K, member 2".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC   2734081 . PMID   15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.

External links

• OR2K2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.