OR11H7

OR11H7
Identifiers
Aliases	OR11H7 , OR11H7P, olfactory receptor family 11 subfamily H member 7 (gene/pseudogene)
External IDs	GeneCards: OR11H7
Gene ontology
Molecular function	G protein-coupled receptor activity ; olfactory receptor activity ; signal transducer activity ; G protein-coupled serotonin receptor activity ; neurotransmitter receptor activity ;
Cellular component	integral component of membrane ; plasma membrane ; membrane ; integral component of plasma membrane ; dendrite ;
Biological process	sensory perception of smell ; detection of chemical stimulus involved in sensory perception of smell ; signal transduction ; response to stimulus ; G protein-coupled serotonin receptor signaling pathway ; G protein-coupled receptor signaling pathway ; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger ; chemical synaptic transmission ;
	Sources:Amigo / QuickGO
Orthologs
	390441
	n/a
	ENSG00000258806
	n/a
	Q8NGC8
	n/a
	NM_001348273
	n/a
	NP_001335202
	n/a
	Wikidata
View/Edit Human

Last updated December 03, 2023

Olfactory receptor family 11 subfamily H member 7 (gene/pseudogene) is a protein that in humans is encoded by the OR11H7 gene. ^[2]

Function

In most humans, OR11H7 is a pseudogene, meaning it does not result in the creation of a functional olfactory receptor protein that binds to specific odorants. Some individuals, however, carry a single-nucleotide polymorphism on one or both chromosomes which transforms it from a pseudogene into an intact gene, and they are significantly more likely to exhibit hyperosmia to the chemical isovaleric acid. Isovaleric acid was shown to be a ligand of OR11H7.^[3]

Related Research Articles

Hyperosmia is an increased olfactory acuity, usually caused by a lower threshold for odor. This perceptual disorder arises when there is an abnormally increased signal at any point between the olfactory receptors and the olfactory cortex. The causes of hyperosmia may be genetic, hormonal, environmental or the result of benzodiazepine withdrawal syndrome.

Olfactory receptor 3A1 is a protein that in humans is encoded by the OR3A1 gene.

Olfactory receptor 2W1 is a protein that in humans is encoded by the OR2W1 gene.

Olfactory receptor 11H1 is a protein that in humans is encoded by the OR11H1 gene.

Olfactory receptor 2AE1 is a protein that in humans is encoded by the OR2AE1 gene.

Olfactory receptor 4A5 is a protein that in humans is encoded by the OR4A5 gene.

Olfactory receptor 4P4 is a protein that in humans is encoded by the OR4P4 gene.

Olfactory receptor 51L1 is a protein that in humans is encoded by the OR51L1 gene.

Olfactory receptor 52W1 is a protein that in humans is encoded by the OR52W1 gene.

Olfactory receptor 11H6 is a protein that in humans is encoded by the OR11H6 gene.

Olfactory receptor 4C16 is a protein that in humans is encoded by the OR4C16 gene.

Olfactory receptor 51E1 is a protein that in humans is encoded by the OR51E1 gene.

Olfactory receptor 8H1 is a protein that in humans is encoded by the OR8H1 gene.

Olfactory receptor 52E8 is a protein that in humans is encoded by the OR52E8 gene.

Olfactory receptor 8H3 is a protein that in humans is encoded by the OR8H3 gene.

Olfactory receptor 11H4 is a protein that in humans is encoded by the OR11H4 gene.

Olfactory receptor 4D9 is a protein that in humans is encoded by the OR4D9 gene.

Olfactory receptor 5M10 is a protein that in humans is encoded by the OR5M10 gene.

Olfactory receptor 4A47 is a protein that in humans is encoded by the OR4A47 gene.

Olfactory receptor family 1 subfamily E member 3 (gene/pseudogene) is a protein that in humans is encoded by the OR1E3 gene.

References

↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Olfactory receptor family 11 subfamily H member 7 (gene/pseudogene)" . Retrieved 2020-04-13.
↑ Menashe I, Abaffy T, Hasin Y, Goshen S, Yahalom V, Luetje CW, Lancet D (October 2007). "Genetic elucidation of human hyperosmia to isovaleric acid". PLOS Biology. 5 (11): e284. doi: 10.1371/journal.pbio.0050284 . PMC 2043052 . PMID 17973576.

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[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-2] "Entrez Gene: Olfactory receptor family 11 subfamily H member 7 (gene/pseudogene)" . Retrieved 2020-04-13.

[3] Menashe I, Abaffy T, Hasin Y, Goshen S, Yahalom V, Luetje CW, Lancet D (October 2007). "Genetic elucidation of human hyperosmia to isovaleric acid". PLOS Biology. 5 (11): e284. doi: 10.1371/journal.pbio.0050284 . PMC 2043052 . PMID 17973576.

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