OR11H7

OR11H7
Identifiers
Aliases	OR11H7 , OR11H7P, olfactory receptor family 11 subfamily H member 7 (gene/pseudogene)
External IDs	MGI: 3030580; GeneCards: OR11H7; OMA:OR11H7 - orthologs
Gene location (Mouse) Chr. Chromosome 14 (mouse) [1] Band 14|14 C1 Start 50,884,540 bp [1] End 50,891,640 bp [1]
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity G protein-coupled serotonin receptor activity neurotransmitter receptor activity Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane dendrite Biological process sensory perception of smell detection of chemical stimulus involved in sensory perception of smell signal transduction response to stimulus G protein-coupled serotonin receptor signaling pathway G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 390441 258295 Ensembl ENSG00000258806 ENSMUSG00000058188 UniProt Q8NGC8 E9Q840 RefSeq (mRNA) NM_001348273 NM_146298 RefSeq (protein) NP_001335202 NP_666410 Location (UCSC) n/a Chr 14: 50.88 – 50.89 Mb PubMed search [2] [3]
Wikidata
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Olfactory receptor family 11 subfamily H member 7 (gene/pseudogene) is a protein that in humans is encoded by the OR11H7 gene. ^[4]

Function

In most humans, OR11H7 is a pseudogene, meaning it does not result in the creation of a functional olfactory receptor protein that binds to specific odorants, although it may be functional in others. Other individuals, however, carry a single-nucleotide polymorphism on one or both chromosomes which transforms it from a pseudogene into an intact gene, and they are significantly more likely to exhibit hyperosmia to the chemical isovaleric acid. Isovaleric acid was shown to be a ligand of OR11H7. ^[5]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000058188 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: Olfactory receptor family 11 subfamily H member 7 (gene/pseudogene)" . Retrieved 2020-04-13.
5. Menashe I, Abaffy T, Hasin Y, Goshen S, Yahalom V, Luetje CW, Lancet D (October 2007). "Genetic elucidation of human hyperosmia to isovaleric acid". PLOS Biology. 5 (11): e284. doi: 10.1371/journal.pbio.0050284 . PMC   2043052 . PMID   17973576.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.