Oxycodone/paracetamol

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Oxycodone/paracetamol
Combination of
Oxycodone Opioid analgesic
Acetaminophen Anilide analgesic
Clinical data
Trade names Percocet, others
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Routes of
administration 		By mouth
ATC code
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Oxycodone/paracetamol, sold under the brand name Percocet among others, [2] is a fixed-dose combination of the opioid oxycodone with paracetamol (acetaminophen), used to treat moderate to severe pain. [1]

Contents

In 2023, it was the 93rd most commonly prescribed medication in the United States, with more than 7 million prescriptions. [3] [4]

History

The United States Food and Drug Administration (FDA) first approved oxycodone/paracetamol in 1976, under application ANDA 085106. [5]

Society and culture

Percocet is often called perc for short. [6] [7] Since the early 2010s, the medication has commonly been name-dropped in songs from multiple genres, such as Future's 2017 song "Mask Off". [6]

Implicated in deaths

In June 2009, an FDA advisory panel recommended that Percocet, Vicodin, and every other combination of acetaminophen with narcotic analgesics [8] be limited in their sales because of their contributions to an alleged 400 acetaminophen-related deaths in the U.S. each year, that were attributed to acetaminophen overdose and associated liver damage. [9]

In December 2009, a study found a fivefold increase in oxycodone-related deaths in Ontario, Canada (mostly accidental) between 1991 and 2007; this led to a doubling of all opioid-related deaths in Ontario over the same period. [10] [11] [12]

References

  1. 1 2 "Percocet- oxycodone hydrochloride and acetaminophen tablet". DailyMed. Retrieved 17 October 2021.
  2. ↑ "Oxycodone / Acetaminophen: Uses, Dosage & More". Drugs.com. 5 March 2023. Retrieved 7 February 2025.
  3. ↑ "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
  4. ↑ "Acetaminophen; Oxycodone Drug Usage Statistics, United States, 2013 - 2023". ClinCalc. Retrieved 18 August 2025.
  5. ↑ "Percocet: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Retrieved 17 October 2021.
  6. 1 2 Levy L (6 February 2018). "These Are the Drugs Influencing Pop Culture Now". Vulture . Archived from the original on 4 February 2025. Retrieved 5 June 2025. Also known as: Percs, blue dynamite. [...] Percocet has become a favorite reference in rap music [...] The rapper Future elevated Perc-worship to a new status in the chorus of his hit 'Mask Off'
  7. ↑ "Oxycodone". US DEA . Archived from the original on 18 April 2025. Retrieved 5 June 2025. Street Title: Hillbilly Heroin, Kicker, OC, Ox, Roxy, Perc, Oxy
  8. ↑ "FDA May Restrict Acetaminophen". WebMD.
  9. ↑ Harris G (30 June 2009). "Ban Is Advised on 2 Top Pills for Pain Relief". The New York Times . Retrieved 22 May 2010.
  10. ↑ Dhalla IA, Mamdani MM, Sivilotti ML, Kopp A, Qureshi O, Juurlink DN (December 2009). "Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodone". CMAJ. 181 (12): 891–6. doi:10.1503/cmaj.090784. PMC   2789126 . PMID   19969578.
  11. ↑ Fischer B, Rehm J (December 2009). "Deaths related to the use of prescription opioids". CMAJ. 181 (12): 881–2. doi:10.1503/cmaj.091791. PMC   2789122 . PMID   19969577.
  12. ↑ "Deaths from opioid use have doubled; five-fold increase in oxycodone deaths". Canadian Medical Association Journal. 7 December 2009. Retrieved 31 May 2012.
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