Interleukin 1 receptor, type I

IL1R1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1G0Y, 1IRA, 1ITB, 4DEP, 4GAF
Identifiers
Aliases	IL1R1 , CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80, Interleukin 1 receptor, type I, interleukin 1 receptor type 1
External IDs	OMIM: 147810; MGI: 96545; HomoloGene: 677; GeneCards: IL1R1; OMA:IL1R1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q11.2-q12.1 Start 102,064,544 bp [1] End 102,179,874 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1 B|1 18.81 cM Start 40,225,080 bp [2] End 40,317,257 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva tibia pericardium corpus epididymis decidua caput epididymis urethra vena cava visceral pleura parietal pleura Top expressed in islet of Langerhans seminal vesicula umbilical cord skin of external ear medullary collecting duct aortic valve primary oocyte ciliary body tunica media of zone of aorta cumulus cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function interleukin-1, type I, activating receptor activity signal transducer activity platelet-derived growth factor receptor binding protease binding protein binding transmembrane signaling receptor activity interleukin-1 receptor activity interleukin-1 binding Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane extracellular region cell surface external side of plasma membrane Biological process cell surface receptor signaling pathway immune response regulation of inflammatory response signal transduction positive regulation of interleukin-1-mediated signaling pathway positive regulation of neutrophil extravasation response to interleukin-1 cytokine-mediated signaling pathway interleukin-1-mediated signaling pathway positive regulation of interferon-gamma production positive regulation of T-helper 1 cell cytokine production inflammatory response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3554 16177 Ensembl ENSG00000115594 ENSMUSG00000026072 UniProt P14778 P13504 RefSeq (mRNA) NM_000877 NM_001288706 NM_001320978 NM_001320980 NM_001320981 NM_001320982 NM_001320983 NM_001320984 NM_001320985 NM_001320986 NM_001123382 NM_008362 RefSeq (protein) NP_000868 NP_001275635 NP_001307907 NP_001307909 NP_001307910 NP_001307911 NP_001307912 NP_001307913 NP_001307914 NP_001307915 NP_001116854 NP_032388 Location (UCSC) Chr 2: 102.06 – 102.18 Mb Chr 1: 40.23 – 40.32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interleukin 1 receptor, type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL1R1 also denotes its human gene. ^[5]

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor antagonist (IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. ^[5]

Interactions

Interleukin 1 receptor, type I has been shown to interact with PIK3R1, ^[6] Myd88 ^{[7] [8]} and IL1RAP. ^[9]

See also

• Cluster of differentiation
• Interleukin 1 receptor, type II

References

1. GRCh38: Ensembl release 89: ENSG00000115594 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026072 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: IL1R1 interleukin 1 receptor, type I".
6. Reddy, S A; Huang J H; Liao W S (November 1997). "Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation". J. Biol. Chem. 272 (46). UNITED STATES: 29167–73. doi: 10.1074/jbc.272.46.29167 . ISSN   0021-9258. PMID   9360994.
7. Burns, K; Clatworthy J; Martin L; Martinon F; Plumpton C; Maschera B; Lewis A; Ray K; Tschopp J; Volpe F (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. 2 (6). ENGLAND: 346–51. doi:10.1038/35014038. ISSN   1465-7392. PMID   10854325. S2CID   32036101.
8. Muzio, M; Ni J; Feng P; Dixit V M (November 1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science . 278 (5343). UNITED STATES: 1612–5. Bibcode:1997Sci...278.1612M. doi:10.1126/science.278.5343.1612. ISSN   0036-8075. PMID   9374458.
9. Huang, J; Gao X; Li S; Cao Z (November 1997). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein". Proc. Natl. Acad. Sci. U.S.A. 94 (24). UNITED STATES: 12829–32. Bibcode:1997PNAS...9412829H. doi: 10.1073/pnas.94.24.12829 . ISSN   0027-8424. PMC   24223 . PMID   9371760.

Further reading

• Copeland NG, Silan CM, Kingsley DM, et al. (1991). "Chromosomal location of murine and human IL-1 receptor genes". Genomics. 9 (1): 44–50. doi:10.1016/0888-7543(91)90219-5. PMID   1672292.
• McMahan CJ, Slack JL, Mosley B, et al. (1991). "A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types". EMBO J. 10 (10): 2821–32. doi:10.1002/j.1460-2075.1991.tb07831.x. PMC   452992 . PMID   1833184.
• Uhl J, Newton RC, Giri JG, et al. (1989). "Identification of IL-1 receptors on human monocytes". J. Immunol. 142 (5): 1576–81. doi: 10.4049/jimmunol.142.5.1576 . PMID   2521881. S2CID   28462235.
• Sims JE, Acres RB, Grubin CE, et al. (1989). "Cloning the interleukin 1 receptor from human T cells". Proc. Natl. Acad. Sci. U.S.A. 86 (22): 8946–50. Bibcode:1989PNAS...86.8946S. doi: 10.1073/pnas.86.22.8946 . PMC   298407 . PMID   2530587.
• Chua AO, Gubler U (1990). "Sequence of the cDNA for the human fibroblast type interleukin-1 receptor". Nucleic Acids Res. 17 (23): 10114. doi:10.1093/nar/17.23.10114. PMC   335251 . PMID   2532321.
• Dower SK, Kronheim SR, Hopp TP, et al. (1987). "The cell surface receptors for interleukin-1 alpha and interleukin-1 beta are identical". Nature. 324 (6094): 266–8. Bibcode:1986Natur.324..266D. doi:10.1038/324266a0. PMID   2946959. S2CID   4233242.
• Rautonen N, Rautonen J, Martin NL, Wara DW (1995). "HIV-1 Tat induces cytokine synthesis by uninfected mononuclear cells". AIDS. 8 (10): 1504–6. doi:10.1097/00002030-199410000-00023. PMID   7818827.
• Vigers GP, Anderson LJ, Caffes P, Brandhuber BJ (1997). "Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta". Nature. 386 (6621): 190–4. Bibcode:1997Natur.386..190V. doi:10.1038/386190a0. PMID   9062193. S2CID   4358379.
• Schreuder H, Tardif C, Trump-Kallmeyer S, et al. (1997). "A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist". Nature. 386 (6621): 194–200. Bibcode:1997Natur.386..194S. doi:10.1038/386194a0. PMID   9062194. S2CID   4266953.
• Rameshwar P, Poddar A, Zhu G, Gascón P (1997). "Receptor induction regulates the synergistic effects of substance P with IL-1 and platelet-derived growth factor on the proliferation of bone marrow fibroblasts". J. Immunol. 158 (7): 3417–24. doi: 10.4049/jimmunol.158.7.3417 . PMID   9120302. S2CID   24164798.
• Reddy SA, Huang JH, Liao WS (1997). "Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation". J. Biol. Chem. 272 (46): 29167–73. doi: 10.1074/jbc.272.46.29167 . PMID   9360994.
• Huang J, Gao X, Li S, Cao Z (1998). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein". Proc. Natl. Acad. Sci. U.S.A. 94 (24): 12829–32. Bibcode:1997PNAS...9412829H. doi: 10.1073/pnas.94.24.12829 . PMC   24223 . PMID   9371760.
• Muzio M, Ni J, Feng P, Dixit VM (1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science. 278 (5343): 1612–5. Bibcode:1997Sci...278.1612M. doi:10.1126/science.278.5343.1612. PMID   9374458.
• Dale M, Nicklin MJ (1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q". Genomics. 57 (1): 177–9. doi:10.1006/geno.1999.5767. PMID   10191101.
• Sizemore N, Leung S, Stark GR (1999). "Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit". Mol. Cell. Biol. 19 (7): 4798–805. doi:10.1128/mcb.19.7.4798. PMC   84278 . PMID   10373529.
• Burns K, Clatworthy J, Martin L, et al. (2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. 2 (6): 346–51. doi:10.1038/35014038. PMID   10854325. S2CID   32036101.
• Vigers GP, Dripps DJ, Edwards CK, Brandhuber BJ (2001). "X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1". J. Biol. Chem. 275 (47): 36927–33. doi: 10.1074/jbc.M006071200 . PMID   10903327.
• Lin H, Ho AS, Haley-Vicente D, et al. (2001). "Cloning and characterization of IL-1HY2, a novel interleukin-1 family member". J. Biol. Chem. 276 (23): 20597–602. doi: 10.1074/jbc.M010095200 . PMID   11278614.
• Joos L, McIntyre L, Ruan J, et al. (2001). "Association of IL-1beta and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers". Thorax. 56 (11): 863–6. doi:10.1136/thorax.56.11.863. PMC   1745962 . PMID   11641511.
• Köller M, Kutscha-Lissberg F, Brom J, et al. (2003). "Influence of low molecular weight heparin (certoparin) and unfractionated heparin on the release of cytokines from human leukocytes". Inflammation. 25 (5): 331–7. doi:10.1023/A:1012883916991. PMID   11820460. S2CID   21831719.

External links

• IL1R1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.