Choline transporter-like protein 1

SLC44A1
Identifiers
Aliases	SLC44A1 , CD92, CDW92, CHTL1, CTL1, solute carrier family 44 member 1, CONATOC
External IDs	OMIM: 606105; MGI: 2140592; HomoloGene: 11137; GeneCards: SLC44A1; OMA:SLC44A1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q31.1-q31.2 Start 105,244,622 bp [1] End 105,439,171 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 B2 Start 53,440,413 bp [2] End 53,622,478 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell inferior ganglion of vagus nerve internal globus pallidus subthalamic nucleus superior vestibular nucleus external globus pallidus pars reticulata ventral tegmental area mucosa of sigmoid colon corpus epididymis Top expressed in hair follicle left colon urothelium deep cerebellar nuclei pyloric antrum transitional epithelium of urinary bladder medullary collecting duct gastric mucosa mucous cell of stomach Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function choline transmembrane transporter activity Cellular component extracellular exosome nucleoplasm mitochondrion plasma membrane integral component of membrane mitochondrial outer membrane membrane Biological process phosphatidylcholine biosynthetic process transmembrane transport choline transport choline catabolic process transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23446 100434 Ensembl ENSG00000070214 ENSMUSG00000028412 UniProt Q8WWI5 Q6X893 RefSeq (mRNA) NM_001286730 NM_022109 NM_080546 NM_001330731 NM_001159633 NM_133891 NM_001374697 RefSeq (protein) NP_001273659 NP_001317660 NP_536856 NP_001153105 NP_598652 NP_001361626 Location (UCSC) Chr 9: 105.24 – 105.44 Mb Chr 4: 53.44 – 53.62 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Choline transporter-like protein 1 is a protein that in humans is encoded by the SLC44A1 gene. ^{[5] [6] [7]}

Papillary glioneuronal tumors characteristically exhibit a gene fusion between SLC44A1 and PRKCA . ^{[8] [9] [10]} Loss of function mutations have been implicated in ethanolamine transport. ^[11]

See also

• Cluster of differentiation
• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000070214 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028412 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wille S, Szekeres A, Majdic O, Prager E, Staffler G, Stöckl J, Kunthalert D, Prieschl EE, Baumruker T, Burtscher H, Zlabinger GJ, Knapp W, Stockinger H (November 2001). "Characterization of CDw92 as a member of the choline transporter-like protein family regulated specifically on dendritic cells". Journal of Immunology. 167 (10): 5795–5804. doi: 10.4049/jimmunol.167.10.5795 . PMID   11698453.
6. O'Regan S, Traiffort E, Ruat M, Cha N, Compaore D, Meunier FM (February 2000). "An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins". Proceedings of the National Academy of Sciences of the United States of America. 97 (4): 1835–40. Bibcode:2000PNAS...97.1835O. doi: 10.1073/pnas.030339697 . PMC   26522 . PMID   10677542.
7. "Entrez Gene: SLC44A1 solute carrier family 44, member 1".
8. Bridge JA, Liu XQ, Sumegi J, Nelson M, Reyes C, Bruch LA, Rosenblum M, Puccioni MJ, Bowdiono BS, McComb RD (2013). "Identification of a Novel, Recurrent SLC44A1-PRKCA Fusion in Papillary Glioneuronal Tumor". Brain Pathology. 23 (2): 121–128. doi: 10.1111/j.1750-3639.2012.00612.x . PMC   8029478 . PMID   22725730.
9. Pages M, Lacroix L, Tauziede-Espariat A, Castel D, Daudigeos-Dubus E, Ridola V, et al. (2015). "Papillary glioneuronal tumors: histological and molecular characteristics and diagnostic value of SLC44A1-PRKCA fusion". Acta Neuropathologica Communications. 3 85. doi: 10.1186/s40478-015-0264-5 . PMC   4681033 . PMID   26671581. 85.
10. Nagaishi M, Nobusawa S, Matsumura N, Kono F, Ishiuchi S, Abe T, Ebato M, Wang Y, Hyodo A, Yokoo H, Nakazato Y (2016). "SLC44A1 – PRKCA fusion in papillary and rosette-forming glioneuronal tumors". Journal of Clinical Neuroscience. 23: 73–75. doi:10.1016/j.jocn.2015.04.021. PMID   26260115. S2CID   140207877.
11. Taylor A, Grapentine S, Ichhpuniani J, Bakovic M (2021). "Choline transporter-like proteins 1 and 2 are newly identified plasma membrane and mitochondrial ethanolamine transporters". J Biol Chem. 296 100604. doi: 10.1016/j.jbc.2021.100604 . PMC   8081925 . PMID   33789160.

Further reading

• Yuan Z, Tie A, Tarnopolsky M, Bakovic M (June 2006). "Genomic organization, promoter activity, and expression of the human choline transporter-like protein 1" (PDF). Physiological Genomics. 26 (1): 76–90. doi:10.1152/physiolgenomics.00107.2005. PMID   16609143. S2CID   8181779. Archived from the original (PDF) on 2019-03-04.
• Fullerton MD, Wagner L, Yuan Z, Bakovic M (April 2006). "Impaired trafficking of choline transporter-like protein-1 at plasma membrane and inhibition of choline transport in THP-1 monocyte-derived macrophages" (PDF). American Journal of Physiology. Cell Physiology. 290 (4): C1230 –C1238. doi:10.1152/ajpcell.00255.2005. PMID   16319125. S2CID   5096497. Archived from the original (PDF) on 2019-02-22.
• Li D, Wang F, Lai M, Chen Y, Zhang JF (February 2005). "A protein phosphatase 2calpha-Ca2+ channel complex for dephosphorylation of neuronal Ca2+ channels phosphorylated by protein kinase C". The Journal of Neuroscience. 25 (8): 1914–23. doi: 10.1523/JNEUROSCI.4790-04.2005 . PMC   6726054 . PMID   15728831.
• Traiffort E, Ruat M, O'Regan S, Meunier FM (March 2005). "Molecular characterization of the family of choline transporter-like proteins and their splice variants". Journal of Neurochemistry. 92 (5): 1116–25. doi: 10.1111/j.1471-4159.2004.02962.x . PMID   15715662. S2CID   30921826.
• Lecomte MJ, De Gois S, Guerci A, Ravassard P, Faucon Biguet N, Mallet J, Berrard S (February 2005). "Differential expression and regulation of the high-affinity choline transporter CHT1 and choline acetyltransferase in neurons of superior cervical ganglia". Molecular and Cellular Neurosciences. 28 (2): 303–13. doi:10.1016/j.mcn.2004.09.014. PMID   15691711. S2CID   20828310.
• Flajolet M, Rakhilin S, Wang H, Starkova N, Nuangchamnong N, Nairn AC, Greengard P (December 2003). "Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3". Proceedings of the National Academy of Sciences of the United States of America. 100 (26): 16006–11. Bibcode:2003PNAS..10016006F. doi: 10.1073/pnas.2136600100 . PMC   307683 . PMID   14663150.
• Takekawa M, Maeda T, Saito H (August 1998). "Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways". The EMBO Journal. 17 (16): 4744–52. doi:10.1093/emboj/17.16.4744. PMC   1170803 . PMID   9707433.

External links

• SLC44A1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)