Frizzled-3

FZD3
Identifiers
Aliases	FZD3 , Fz-3, frizzled class receptor 3
External IDs	OMIM: 606143 MGI: 108476 HomoloGene: 23004 GeneCards: FZD3
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8p21.1 Start 28,494,205 bp [1] End 28,574,267 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14 D1|14 34.09 cM Start 65,429,898 bp [2] End 65,499,912 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 secondary oocyte corpus epididymis middle temporal gyrus endothelial cell entorhinal cortex parietal lobe postcentral gyrus cerebellar vermis pons Top expressed in medial ganglionic eminence olfactory tubercle ventromedial nucleus trigeminal ganglion substantia nigra paraventricular nucleus of hypothalamus arcuate nucleus subiculum median eminence nucleus accumbens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function PDZ domain binding signal transducer activity Wnt-protein binding protein binding transmembrane signaling receptor activity G protein-coupled receptor activity Wnt-activated receptor activity Cellular component cytoplasm lateral plasma membrane membrane plasma membrane apical part of cell presynaptic active zone cell surface axon filopodium tip neuronal cell body dendrite apical plasma membrane integral component of membrane Biological process hair follicle development dopaminergic neuron axon guidance positive regulation of neuroblast proliferation sympathetic ganglion development G protein-coupled receptor signaling pathway negative regulation of execution phase of apoptosis negative regulation of mitotic cell cycle, embryonic serotonergic neuron axon guidance establishment of planar polarity cell proliferation in midbrain neuron migration Wnt signaling pathway commissural neuron axon guidance nervous system development multicellular organism development neural tube closure cell surface receptor signaling pathway inner ear morphogenesis neuron differentiation post-anal tail morphogenesis canonical Wnt signaling pathway midbrain morphogenesis midbrain development signal transduction response to electrical stimulus Wnt signaling pathway, calcium modulating pathway brain development planar cell polarity pathway involved in axon guidance Wnt signaling pathway, planar cell polarity pathway non-canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7976 14365 Ensembl ENSG00000104290 ENSMUSG00000007989 UniProt Q9NPG1 Q61086 RefSeq (mRNA) NM_017412 NM_145866 NM_021458 RefSeq (protein) NP_059108 NP_665873 NP_067433 Location (UCSC) Chr 8: 28.49 – 28.57 Mb Chr 14: 65.43 – 65.5 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Frizzled-3(Fz-3) is a protein that in humans is encoded by the FZD3 gene. ^{[5] [6] [7]}

Function

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. It may play a role in mammalian hair follicle development. ^[7]

The function of this gene is largely derived from mouse studies. Fzd3 in the mouse functions through planar cell polarity signaling instead of the canonical Wnt/beta-catenin pathway. Fzd3 controls axon growth and guidance in the mouse nervous system, and migration of neural crest cells. ^{[8] [9]}

See also

• Frizzled

References

1. GRCh38: Ensembl release 89: ENSG00000104290 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000007989 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kirikoshi H, Koike J, Sagara N, Saitoh T, Tokuhara M, Tanaka K, Sekihara H, Hirai M, Katoh M (Jun 2000). "Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21". Biochem Biophys Res Commun. 271 (1): 8–14. doi:10.1006/bbrc.2000.2578. PMID   10777673.
6. Sala CF, Formenti E, Terstappen GC, Caricasole A (Jul 2000). "Identification, gene structure, and expression of human frizzled-3 (FZD3)". Biochem Biophys Res Commun. 273 (1): 27–34. doi:10.1006/bbrc.2000.2882. PMID   10873558.
7. "Entrez Gene: FZD3 frizzled homolog 3 (Drosophila)".
8. Hua ZL, Smallwood PM, Nathans J (Dec 2013). "Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons". eLife. 2: e01482. doi: 10.7554/eLife.01482 . PMC   3865743 . PMID   24347548.
9. Hua ZL, Jeon S, Caterina MJ, Nathans J (Jul 2014). "Frizzled3 is required for the development of multiple axon tracts in the mouse central nervous system". Proc Natl Acad Sci U S A. 111 (29): E3005-14. Bibcode:2014PNAS..111E3005H. doi: 10.1073/pnas.1406399111 . PMC   4115534 . PMID   24799694.

Further reading

• Katoh M (2002). "GIPC gene family (Review)". Int. J. Mol. Med. 9 (6): 585–9. doi:10.3892/ijmm.9.6.585. PMID   12011974.
• Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. Bibcode:1997PNAS...94.6770F. doi: 10.1073/pnas.94.13.6770 . PMC   21233 . PMID   9192640.
• Wright M, Aikawa M, Szeto W, Papkoff J (1999). "Identification of a Wnt-responsive signal transduction pathway in primary endothelial cells". Biochem. Biophys. Res. Commun. 263 (2): 384–8. doi:10.1006/bbrc.1999.1344. PMID   10491302.
• Hung BS, Wang XQ, Cam GR, Rothnagel JA (2001). "Characterization of mouse Frizzled-3 expression in hair follicle development and identification of the human homolog in keratinocytes". J. Invest. Dermatol. 116 (6): 940–6. doi: 10.1046/j.1523-1747.2001.01336.x . PMID   11407985.
• Katsu T, Ujike H, Nakano T, Tanaka Y, Nomura A, Nakata K, Takaki M, Sakai A, Uchida N, Imamura T, Kuroda S (2004). "The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia" . Neurosci. Lett. 353 (1): 53–6. doi:10.1016/j.neulet.2003.09.017. PMID   14642436. S2CID   109984.
• Zhang Y, Yu X, Yuan Y, Ling Y, Ruan Y, Si T, Lu T, Wu S, Gong X, Zhu Z, Yang J, Wang F, Zhang D (2005). "Positive association of the human frizzled 3 (FZD3) gene haplotype with schizophrenia in Chinese Han population". Am. J. Med. Genet. B Neuropsychiatr. Genet. 129 (1): 16–9. doi:10.1002/ajmg.b.30076. PMID   15274031. S2CID   33599450.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC   2286551 . PMID   15340161.
• Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID   15370539. S2CID   32817238.
• Hashimoto R, Suzuki T, Iwata N, Yamanouchi Y, Kitajima T, Kosuga A, Tatsumi M, Ozaki N, Kamijima K, Kunugi H (2005). "Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders". Journal of Neural Transmission. 112 (2): 303–7. doi:10.1007/s00702-004-0264-2. PMID   15657645. S2CID   22324795.

External links

• "Frizzled Receptors: FZD₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.