Frizzled-5

FZD5
Identifiers
Aliases	FZD5 , C2orf31, HFZ5, frizzled class receptor 5
External IDs	OMIM: 601723 MGI: 108571 HomoloGene: 2590 GeneCards: FZD5
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q33.3 Start 207,762,598 bp [1] End 207,769,906 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1 C2|1 32.74 cM Start 64,769,717 bp [2] End 64,776,910 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa lower lobe of lung duodenum palpebral conjunctiva kidney tubule visceral pleura tibia cancellous bone liver right lobe of liver Top expressed in median eminence hair follicle Epithelium of stomach ciliary body left colon arcuate nucleus Paneth cell calvaria ileum lacrimal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function amyloid-beta binding signal transducer activity Wnt-protein binding protein binding protein kinase binding ubiquitin protein ligase binding transmembrane signaling receptor activity Wnt-activated receptor activity G protein-coupled receptor activity Cellular component clathrin-coated endocytic vesicle membrane Golgi apparatus early endosome membrane membrane bicellular tight junction Golgi membrane plasma membrane cell surface early endosome perinuclear region of cytoplasm integral component of membrane Biological process G protein-coupled receptor signaling pathway T cell differentiation in thymus chorionic trophoblast cell differentiation positive regulation of protein targeting to mitochondrion positive regulation of JUN kinase activity apoptotic process involved in morphogenesis regulation of chorionic trophoblast cell proliferation regulation of bicellular tight junction assembly regulation of canonical Wnt signaling pathway cellular response to molecule of bacterial origin positive regulation of interferon-gamma production embryonic axis specification labyrinthine layer blood vessel development cell maturation Wnt signaling pathway embryonic camera-type eye development multicellular organism development cell surface receptor signaling pathway vasculature development regulation of autophagy of mitochondrion branching involved in labyrinthine layer morphogenesis embryonic camera-type eye morphogenesis post-embryonic camera-type eye development positive regulation of T cell cytokine production angiogenesis neuron differentiation Wnt signaling pathway involved in dorsal/ventral axis specification canonical Wnt signaling pathway synapse assembly syncytiotrophoblast cell differentiation involved in labyrinthine layer development anterior/posterior axis specification, embryo Spemann organizer formation positive regulation of transcription by RNA polymerase II negative regulation of cell population proliferation signal transduction Wnt signaling pathway, calcium modulating pathway Wnt signaling pathway, planar cell polarity pathway beta-catenin destruction complex disassembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7855 14367 Ensembl ENSG00000163251 ENSMUSG00000045005 UniProt Q13467 Q9EQD0 RefSeq (mRNA) NM_030804 NM_003468 NM_001033193 NM_001042659 NM_022721 RefSeq (protein) NP_003459 NP_001036124 NP_073558 Location (UCSC) Chr 2: 207.76 – 207.77 Mb Chr 1: 64.77 – 64.78 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Frizzled-5(Fz-5) is a protein that in humans is encoded by the FZD5 gene. ^{[5] [6] [7]}

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. Fz-5 is believed to be the receptor for the Wnt5A ligand. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000163251 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000045005 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Jun 1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled". J Biol Chem. 271 (8): 4468–76. doi: 10.1074/jbc.271.8.4468 . PMID   8626800.
6. Saitoh T, Hirai M, Katoh M (Jun 2001). "Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region". Int J Oncol. 19 (1): 105–10. doi:10.3892/ijo.19.1.105. PMID   11408929.
7. "Entrez Gene: FZD5 frizzled homolog 5 (Drosophila)".

Further reading

• He X, Saint-Jeannet JP, Wang Y, et al. (1997). "A member of the Frizzled protein family mediating axis induction by Wnt-5A". Science. 275 (5306): 1652–4. doi:10.1126/science.275.5306.1652. PMID   9054360. S2CID   36777692.
• Finch PW, He X, Kelley MJ, et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. Bibcode:1997PNAS...94.6770F. doi: 10.1073/pnas.94.13.6770 . PMC   21233 . PMID   9192640.
• Tanaka S, Akiyoshi T, Mori M, et al. (1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164–9. Bibcode:1998PNAS...9510164T. doi: 10.1073/pnas.95.17.10164 . PMC   21479 . PMID   9707618.
• Tamai K, Semenov M, Kato Y, et al. (2000). "LDL-receptor-related proteins in Wnt signal transduction". Nature. 407 (6803): 530–5. Bibcode:2000Natur.407..530T. doi:10.1038/35035117. PMID   11029007. S2CID   4400159.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Yao R, Maeda T, Takada S, Noda T (2001). "Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled". Biochem. Biophys. Res. Commun. 286 (4): 771–8. doi:10.1006/bbrc.2001.5430. PMID   11520064.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Weidler C, Schaumburger J, Miller LE, et al. (2004). "Synovial density of frizzled 5-positive cells does not differ between patients with RA and OA and is independent of inflammation". J. Rheumatol. 31 (9): 1874–5. PMID   15338479.
• Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID   15370539. S2CID   32817238.
• Holmen SL, Robertson SA, Zylstra CR, Williams BO (2005). "Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein". Biochem. Biophys. Res. Commun. 328 (2): 533–9. doi:10.1016/j.bbrc.2005.01.009. PMID   15694380.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID   15815621.
• Blumenthal A, Ehlers S, Lauber J, et al. (2006). "The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation". Blood. 108 (3): 965–73. doi: 10.1182/blood-2005-12-5046 . PMID   16601243.
• Yamamoto H, Komekado H, Kikuchi A (2006). "Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin". Dev. Cell. 11 (2): 213–23. doi: 10.1016/j.devcel.2006.07.003 . PMID   16890161.
• Katoh Y, Katoh M (2007). "Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer". Int. J. Oncol. 30 (3): 751–5. doi: 10.3892/ijo.30.3.751 . PMID   17273778.

External links

• "Frizzled Receptors: FZD₅". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.