This is a list of infectious diseases arranged by name, along with the infectious agents that cause them, the vaccines that can prevent or cure them when they exist and their current status. Some on the list are vaccine-preventable diseases.
Infectious agent | Common name | Diagnosis | Treatment | Vaccine(s) |
---|---|---|---|---|
Acinetobacter baumannii | Acinetobacter infections | Culture | Supportive care | No |
Actinomyces israelii , Actinomyces gerencseriae and Propionibacterium propionicus | Actinomycosis | Histologic findings | Penicillin, doxycycline, and sulfonamides | No |
Adenoviridae | Adenovirus infection | Antigen detection, polymerase chain reaction assay, virus isolation, and serology | Most infections are mild and require no therapy or only symptomatic treatment. | Under research [1] |
Trypanosoma brucei | African sleeping sickness (African trypanosomiasis) | Identification of trypanosomes in a sample by microscopic examination | Fexinidazole by mouth or pentamidine by injection for T. b. gambiense. Suramin by injection is used for T. b. rhodesiense | Under research [2] |
HIV (Human immunodeficiency virus) | AIDS (acquired immunodeficiency syndrome) | Antibody test, p24 antigen test, PCR | Treatment is typically a non-nucleoside reverse transcriptase inhibitor (NNRTI) plus two nucleoside analog reverse transcriptase inhibitors (NRTIs) | Under research [3] |
Entamoeba histolytica | Amoebiasis | Microscopy | Those with symptoms require treatment with an amoebicidal tissue-active agent and a luminal cysticidal agent. Individuals that are asymptomatic only need a luminal cysticidal agent. | No |
Anaplasma species | Anaplasmosis | indirect immunofluorescence antibody assay for IgG | Tetracycline drugs (including tetracycline, chlortetracycline, oxytetracycline, rolitetracycline, doxycycline, and minocycline) and imidocarb | No |
Angiostrongylus | Angiostrongyliasis | Lumbar puncture, brain imaging, serology | Albendazole | No |
Anisakis | Anisakiasis | Gastroscopic examination, or histopathologic examination | Albendazole | No |
Bacillus anthracis | Anthrax | Culture, PCR | Large doses of intravenous and oral antibiotics, such as fluoroquinolones (ciprofloxacin), doxycycline, erythromycin, vancomycin, or penicillin | Yes |
Arcanobacterium haemolyticum | Arcanobacterium haemolyticum infection | Culture in human blood agar plates | erythromycin (proposed as the first-line drug), clindamycin, gentamicin, and cephalosporins | No |
Junin virus | Argentine hemorrhagic fever | Yes [4] | ||
Ascaris lumbricoides | Ascariasis | Fecal smear | Albendazole, mebendazole, levamisole and pyrantel pamoate | No |
Aspergillus species | Aspergillosis | Chest X-ray and CT, microscopy by silver stains | Voriconazole and liposomal amphotericin B in combination with surgical debridement | No |
Astroviridae species | Astrovirus infection | Electron microscopy, enzyme-immunoassay (ELISA), immunofluorescence, and polymerase chain reaction | Supportive care | No |
Babesia species | Babesiosis | Giemsa-stained thin-film blood smear | Atovaquone and azithromycin. In life-threatening cases, exchange transfusion is performed. | No |
Bacillus cereus | Bacillus cereus infection | Culture | Vancomycin | No |
multiple bacteria | Bacterial meningitis | Lumbar puncture (contraindicated if there is a mass in the brain or the intracranial pressure is elevated), CT or MRI | Antibiotics | No |
multiple bacteria | Bacterial pneumonia | Sputum Gram stain and culture, Chest radiography | Antibiotics | No |
List of bacterial vaginosis microbiota | Bacterial vaginosis | Gram stain and whiff test | Metronidazole or clindamycin | No |
Bacteroides species | Bacteroides infection | No | ||
Balantidium coli | Balantidiasis | microscopic examination of stools, or colonoscopy or sigmoidoscopy | Tetracycline, metronidazole or iodoquinol | No |
Bartonella | Bartonellosis | microscopy, serology, and PCR | Antibiotics | No |
Baylisascaris species | Baylisascaris infection | No | ||
BK virus | BK virus infection | No | ||
Piedraia hortae | Black piedra | Stain or culture | Antifungal shampoos such as pyrithione zinc, formaldehyde and salicylic acid | No |
Blastocystis species | Blastocystosis | microscopic examination of a chemically preserved stool specimen | Lack of scientific study to support the efficacy of any particular treatment | No |
Blastomyces dermatitidis | Blastomycosis | KOH prep, cytology, or histology | Itraconazole or ketoconazole | No |
Machupo virus | Bolivian hemorrhagic fever | No | ||
Clostridium botulinum ; Note: Botulism is not an infection by Clostridium botulinum but caused by the intake of botulinum toxin. | Botulism (and Infant botulism) | Enzyme-linked immunosorbent assays (ELISAs), electrochemiluminescent (ECL) tests | Botulism antitoxin and supportive care | No |
Sabiá virus | Brazilian hemorrhagic fever | No | ||
Brucella species | Brucellosis | Culture | Tetracyclines, rifampicin, and the aminoglycosides streptomycin and gentamicin | Yes [5] |
Yersinia pestis | Bubonic plague | Culture | Aminoglycosides such as streptomycin and gentamicin, tetracyclines (especially doxycycline), and the fluoroquinolone ciprofloxacin | Under research [6] |
usually Burkholderia cepacia and other Burkholderia species | Burkholderia infection | No | ||
Mycobacterium ulcerans | Buruli ulcer | real-time PCR | The most widely used antibiotic regimen is once daily oral rifampicin plus twice daily oral clarithromycin. | No |
Caliciviridae species | Calicivirus infection (Norovirus and Sapovirus) | No | ||
Campylobacter species | Campylobacteriosis | Stool culture | Erythromycin can be used in children, and tetracycline in adults. | No |
usually Candida albicans and other Candida species | Candidiasis (Moniliasis; Thrush) | oral candidiasis, the person's mouth for white patches and irritation. vaginal candidiasis, vaginal itching or soreness, pain during sexual intercourse | Antifungal medications | No |
Intestinal disease by Capillaria philippinensis , hepatic disease by Capillaria hepatica and pulmonary disease by Capillaria aerophila | Capillariasis | No | ||
Streptococcus mutans | Dental caries | Under research [7] | ||
Bartonella bacilliformis | Carrion's disease | Peripheral blood smear with Giemsa stain, Columbia blood agar cultures, immunoblot, indirect immunofluorescence, and PCR | Fluoroquinolones (such as ciprofloxacin) or chloramphenicol in adults and chloramphenicol plus beta-lactams in children | No |
Bartonella henselae | Cat-scratch disease | Polymerase chain reaction | Azithromycin | No |
usually Group A Streptococcus and Staphylococcus | Cellulitis | history and physical examination | Penicillinase-resistant semisynthetic penicillin or a first-generation cephalosporin | No |
Trypanosoma cruzi | Chagas disease (American trypanosomiasis) | Microscopic examination of fresh anticoagulated blood, or its buffy coat, for motile parasites; or by preparation of thin and thick blood smears stained with Giemsa. | Benznidazole and nifurtimox (though benznidazole is the only drug available in most of Latin America) | Under research [8] |
Haemophilus ducreyi | Chancroid | Clinical diagnosis | The CDC recommendation is either a single oral dose (1 gram) of azithromycin, a single IM dose (250 mg) of ceftriaxone, oral (500 mg) of erythromycin three times a day for seven days, or oral (500 mg) of ciprofloxacin twice a day for three days. | No |
Varicella zoster virus (VZV) | Chickenpox | The diagnosis of chickenpox is primarily based on the signs and symptoms, with typical early symptoms followed by a characteristic rash. | Aciclovir | Yes |
Alphavirus | Chikungunya | Laboratory criteria include a decreased lymphocyte count consistent with viremia. Definitive laboratory diagnosis can be accomplished through viral isolation, RT-PCR, or serological diagnosis. | Supportive care | Under research [9] |
Chlamydia trachomatis | Chlamydia | Nucleic acid amplification tests (NAAT), such as polymerase chain reaction (PCR), transcription mediated amplification (TMA), and the DNA strand displacement amplification (SDA) | azithromycin, doxycycline, erythromycin, levofloxacin or ofloxacin | No |
Chlamydophila pneumoniae | Chlamydophila pneumoniae infection (Taiwan acute respiratory agent or TWAR) | No | ||
Vibrio cholerae | Cholera | A rapid dipstick test is available. | oral rehydration therapy (ORT) | Yes |
usually Fonsecaea pedrosoi | Chromoblastomycosis | microscopy (KOH scrapings) | Itraconazole, an antifungal azole, is given orally, with or without flucytosine. | No |
Batrachochytrium dendrabatidis | Chytridiomycosis | No | ||
Clonorchis sinensis | Clonorchiasis | No | ||
Clostridioides difficile | Clostridioides difficile colitis | Colonoscopy or sigmoidoscopy, cytotoxicity assay, toxin ELISA | Vancomycin or fidaxomicin by mouth | No |
Coccidioides immitis and Coccidioides posadasii | Coccidioidomycosis | No | ||
Colorado tick fever virus (CTFV) | Colorado tick fever (CTF) | No | ||
usually rhinoviruses and coronaviruses | Common cold (Acute viral rhinopharyngitis; Acute coryza) | Based on symptoms | Supportive care | No |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) | Coronavirus disease 2019 (COVID-19) | Yes | ||
Coxsackie B virus | Coxsackie B virus infection | Enterovirus infection is diagnosed mainly via serological tests such as ELISA and from cell culture. | There is no well-accepted treatment for the Coxsackie B group of viruses. | Under research [10] |
PRNP | Creutzfeldt–Jakob disease (CJD) | No | ||
Crimean-Congo hemorrhagic fever virus | Crimean-Congo hemorrhagic fever (CCHF) | No | ||
Cryptococcus neoformans | Cryptococcosis | India ink of the cerebrospinal fluid (CSF) | Intravenous Amphotericin B combined with flucytosine by mouth | No |
Cryptosporidium species | Cryptosporidiosis | No | ||
usually Ancylostoma braziliense ; multiple other parasites | Cutaneous larva migrans (CLM) | No | ||
Cyclospora cayetanensis | Cyclosporiasis | No | ||
Taenia solium | Cysticercosis | No | ||
Cytomegalovirus | Cytomegalovirus infection | Blood and urine tests, biopsy | Cidofovir, foscarnet, ganciclovir, valganciclovir | Under research [11] |
Dengue viruses (DEN-1, DEN-2, DEN-3 and DEN-4) – Flaviviruses | Dengue fever | Clinical diagnosis | Treatment depends on the symptoms. | Yes |
Green algae Desmodesmus armatus | Desmodesmus infection | No | ||
Dientamoeba fragilis | Dientamoebiasis | No | ||
Corynebacterium diphtheriae | Diphtheria | Laboratory criteria
Toxin demonstration
Clinical criteria
| Metronidazole, Erythromycin, Procaine penicillin G | Yes |
Diphyllobothrium | Diphyllobothriasis | No | ||
Dracunculus medinensis | Dracunculiasis | No | ||
Eastern equine encephalitis virus | Eastern equine encephalitis (EEE) | Blood tests | Corticosteroids, anticonvulsants, and supportive measures (treating symptoms) | Under research [12] |
Ebolavirus (EBOV) | Ebola hemorrhagic fever | Yes | ||
Echinococcus species | Echinococcosis | Imaging, Serology test | Surgical removal of the cysts combined with chemotherapy | No |
Ehrlichia species | Ehrlichiosis | Under research [13] | ||
Enterobius vermicularis | Enterobiasis (Pinworm infection) | No | ||
Enterococcus species | Enterococcus infection | No | ||
Enterovirus species | Enterovirus infection | No | ||
Rickettsia prowazekii | Epidemic typhus | No | ||
Parvovirus B19 | Erythema infectiosum (Fifth disease) | No | ||
Human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) | Exanthem subitum (Sixth disease) | No | ||
Fasciola hepatica and Fasciola gigantica | Fasciolasis | No | ||
Fasciolopsis buski | Fasciolopsiasis | No | ||
PRNP | Fatal familial insomnia (FFI) | No | ||
Filarioidea superfamily | Filariasis | No | ||
Clostridium perfringens | Food poisoning by Clostridium perfringens | Stool test | Supportive care | No |
multiple | Free-living amebic infection | No | ||
Fusobacterium species | Fusobacterium infection | No | ||
usually Clostridium perfringens ; other Clostridium species | Gas gangrene (Clostridial myonecrosis) | No | ||
Geotrichum candidum | Geotrichosis | No | ||
PRNP | Gerstmann-Sträussler-Scheinker syndrome (GSS) | No | ||
Giardia lamblia | Giardiasis | Detection of antigens on the surface of organisms in stool | Treatment is not always necessary. If medications are needed, a nitroimidazole medication is used such as metronidazole, tinidazole, secnidazole or ornidazole. | No |
Burkholderia mallei | Glanders | No | ||
Gnathostoma spinigerum and Gnathostoma hispidum | Gnathostomiasis | No | ||
Neisseria gonorrhoeae | Gonorrhea | Gram stain and culture | Ceftriaxone by injection and azithromycin by mouth | Under research [14] |
Klebsiella granulomatis | Granuloma inguinale (Donovanosis) | No | ||
Streptococcus pyogenes | Group A streptococcal infection | Culture | Penicillin | No |
Streptococcus agalactiae | Group B streptococcal infection | Gram stain | Penicillin and ampicillin | No |
Haemophilus influenzae | Haemophilus influenzae infection | Gram stain | In severe cases, cefotaxime and ceftriaxone delivered into the bloodstream, and for the less severe cases, an association of ampicillin and sulbactam, cephalosporins of the second and third generation, or fluoroquinolones are preferred. | Yes |
Enteroviruses, mainly Coxsackie A virus and enterovirus 71 (EV71) | Hand, foot and mouth disease (HFMD) | A diagnosis usually can be made by the presenting signs and symptoms alone. If the diagnosis is unclear, a throat swab or stool specimen may be taken. | Medications are usually not needed as hand, foot, and mouth disease is a viral disease that typically resolves on its own. | Under research [15] [16] |
Sin Nombre virus | Hantavirus Pulmonary Syndrome (HPS) | No | ||
Heartland virus | Heartland virus disease | No | ||
Helicobacter pylori | Helicobacter pylori infection | No | ||
Escherichia coliO157:H7, O111 and O104:H4 | Hemolytic-uremic syndrome (HUS) | First diagnosis of aHUS is often made in the context of an initial, complement-triggering infection, and Shiga-toxin has also been implicated as a trigger that identifies patients with aHUS. | Treatment involves supportive care and may include dialysis, steroids, blood transfusions, and plasmapheresis. | No |
Bunyaviridae species | Hemorrhagic fever with renal syndrome (HFRS) | HFRS is difficult to diagnose on clinical grounds alone and serological evidence is often needed. | There is no cure for HFRS. Treatment involves supportive therapy including renal dialysis. | No |
Hendra virus | Hendra virus infection | No | ||
Hepatitis A virus | Hepatitis A | Blood tests | Supportive care, liver transplantation | Yes |
Hepatitis B virus | Hepatitis B | Blood tests | Antiviral medication (tenofovir, interferon), liver transplantation | Yes |
Hepatitis C virus | Hepatitis C | Blood testing for antibodies or viral RNA | Antivirals (sofosbuvir, simeprevir, others) | Under research [17] |
Hepatitis D Virus | Hepatitis D | Immunoglobulin G | Antivirals, pegylated interferon alpha | No |
Hepatitis E virus | Hepatitis E | Hepatitis E virus (HEV) | Rest, ribavirin (if chronic) | Yes |
Herpes simplex virus 1 and 2 (HSV-1 and HSV-2) | Herpes simplex | Based on symptoms, PCR, viral culture | Aciclovir, valaciclovir, paracetamol (acetaminophen), topical lidocaine | No |
Histoplasma capsulatum | Histoplasmosis | Histoplasmosis can be diagnosed by samples containing the fungus taken from sputum (via bronchoalveolar lavage), blood, or infected organs. | In the majority of immunocompetent individuals, histoplasmosis resolves without any treatment. Typical treatment of severe disease first involves treatment with amphotericin B, followed by oral itraconazole. | No |
Ancylostoma duodenale and Necator americanus | Hookworm infection | Under research [18] | ||
Human bocavirus (HBoV) | Human bocavirus infection | No | ||
Ehrlichia ewingii | Human ewingii ehrlichiosis | The diagnosis can be confirmed by using PCR. A peripheral blood smear can also be examined for intracytoplasmic inclusions called morulae. | Doxycycline | No |
Anaplasma phagocytophilum | Human granulocytic anaplasmosis (HGA) | PCR | Doxycycline | No |
Human metapneumovirus (hMPV) | Human metapneumovirus infection | No | ||
Ehrlichia chaffeensis | Human monocytic ehrlichiosis | PCR | Doxycycline | No |
One of the human papillomaviruses | Human papillomavirus (HPV) infection | Yes | ||
Human parainfluenza viruses (HPIV) | Human parainfluenza virus infection | Under research [19] [20] | ||
Human T-lymphotropic virus 1 (HTLV-1) | Human T-lymphotropic virus 1 infection | Under research [21] [22] | ||
Hymenolepis nana and Hymenolepis diminuta | Hymenolepiasis | Examination of the stool for eggs and parasites | Praziquantel, niclosamide | No |
Epstein–Barr virus (EBV) | Epstein–Barr virus infectious mononucleosis (Mono) | Diagnostic modalities for infectious mononucleosis include:
| Infectious mononucleosis is generally self-limiting, so only symptomatic or supportive treatments are used. | Under research [23] |
Orthomyxoviridae species | Influenza (flu) | Diagnostic methods that can identify influenza include viral cultures, antibody- and antigen-detecting tests, and nucleic acid-based tests. | Treatment of influenza in cases of mild or moderate illness is supportive and includes anti-fever medications such as acetaminophen and ibuprofen, adequate fluid intake to avoid dehydration, and resting at home. | Under research [24] |
Yes | ||||
Isospora belli | Isosporiasis | Microscopic demonstration of the large typically shaped oocysts is the basis for diagnosis. | Trimethoprim-sulfamethoxazole | No |
Japanese encephalitis virus | Japanese encephalitis | Available tests detecting JE virus-specific IgM antibodies in serum and/or cerebrospinal fluid, for example by IgM capture ELISA. | Supportive | Yes |
unknown; evidence supports that it is infectious | Kawasaki disease | Based on symptoms, ultrasound of the heart | Aspirin, immunoglobulin | No |
multiple | Keratitis | Infectious keratitis generally requires urgent antibacterial, antifungal, or antiviral therapy to eliminate the pathogen. | No | |
Kingella kingae | Kingella kingae infection | No | ||
PRNP | Kuru | Autopsy | None | No |
Lassa virus | Lassa fever | Laboratory testing | Supportive | No |
Legionella pneumophila | Legionellosis (Legionnaires' disease) | Urinary antigen test, sputum culture | Effective antibiotics include most macrolides, tetracyclines, ketolides, and quinolones. | No |
Legionella pneumophila | Pontiac fever | No | ||
Leishmania species | Leishmaniasis | Hematology laboratory by direct visualization of the amastigotes (Leishman–Donovan bodies). | For visceral leishmaniasis in India, South America, and the Mediterranean, liposomal amphotericin B is the recommended treatment and is often used as a single dose. | Under research [25] |
Mycobacterium leprae and Mycobacterium lepromatosis | Leprosy | In countries where people are frequently infected, a person is considered to have leprosy if they have one of the following two signs:
| Rifampicin, dapsone, clofazimine | Under research [26] |
Leptospira species | Leptospirosis | Testing blood for antibodies against the bacterium or its DNA | Doxycycline, penicillin, ceftriaxone | Yes |
Listeria monocytogenes | Listeriosis | Culture of blood or spinal fluid | Ampicillin, gentamicin | No |
Borrelia burgdorferi , Borrelia garinii , and Borrelia afzelii | Lyme disease (Lyme borreliosis) | Based on symptoms, tick exposure, blood tests | Doxycycline, amoxicillin, ceftriaxone, cefuroxime | Under research [27] |
Wuchereria bancrofti and Brugia malayi | Lymphatic filariasis (Elephantiasis) | Microscopic examination of blood | Albendazole with ivermectin or diethylcarbamazine | No |
Lymphocytic choriomeningitis virus (LCMV) | Lymphocytic choriomeningitis | Blood test | Symptomatic and supportive | No |
Plasmodium species | Malaria | Examination of the blood, antigen detection tests | Antimalarial medication | Yes |
Marburg virus | Marburg hemorrhagic fever (MHF) | Blood test | Supportive | Under research [28] |
Measles virus | Measles | Onset of fever and malaise about 10 days after exposure to the measles virus, followed by the emergence of cough, coryza, and conjunctivitis that worsen in severity over 4 days of appearing. Observation of Koplik's spots is also diagnostic. | Supportive care | Yes |
Middle East respiratory syndrome–related coronavirus | Middle East respiratory syndrome (MERS) | rRT-PCR testing | Symptomatic and supportive | Under research [29] |
Burkholderia pseudomallei | Melioidosis (Whitmore's disease) | Growing the bacteria in culture mediums | Ceftazidime, meropenem, co-trimoxazole | No |
multiple | Meningitis | Lumbar puncture | Antibiotics, antivirals, steroids | No |
Neisseria meningitidis | Meningococcal disease | Treatment in primary care usually involves intramuscular administration of benzylpenicillin. Once in the hospital, the antibiotics of choice are usually IV broad spectrum 3rd generation cephalosporins. | Yes | |
usually Metagonimus yokagawai | Metagonimiasis | Metagonimiasis is diagnosed by eggs seen in feces. | Praziquantel | No |
Microsporidia phylum | Microsporidiosis | PCR | Fumagillin has been used in the treatment. Another agent used is albendazole. | No |
Molluscum contagiosum virus (MCV) | Molluscum contagiosum (MC) | Based on appearance | Cimetidine, podophyllotoxin | No |
Monkeypox virus | Mpox | Testing for viral DNA | Supportive, antivirals, vaccinia immune globulin | Yes |
Mumps virus | Mumps | Antibody testing, viral cultures, and reverse transcription polymerase chain reaction | Supportive | Yes |
Rickettsia typhi | Murine typhus (Endemic typhus) | Early diagnosis continued to be based on clinical suspicion. | The most effective antibiotics include tetracycline and chloramphenicol. | No |
Mycoplasma pneumoniae | Mycoplasma pneumonia | Chest X-Ray, Chest CT, blood test | Erythromycin, doxycycline | No |
Mycoplasma genitalium | Mycoplasma genitalium infection | Nucleic acid amplification test | Azithromycin, moxifloxacin | No |
numerous species of bacteria (Actinomycetoma) and fungi (Eumycetoma) | Mycetoma | Ultrasound, fine needle aspiration | Antibiotics or antifungal medication | No |
parasitic dipterous fly larvae | Myiasis | Examination and serologic testing | Petroleum jelly over the central punctum | No |
most commonly Chlamydia trachomatis and Neisseria gonorrhoeae | Neonatal conjunctivitis (Ophthalmia neonatorum) | Antibiotic ointment (erythromycin, tetracycline, or rarely silver nitrate or Argyrol) | No | |
Nipah virus | Nipah virus infection | Under research [30] | ||
Norovirus | Norovirus | Based on symptoms | Supportive care | Under research [31] |
PRNP | (New) Variant Creutzfeldt–Jakob disease (vCJD, nvCJD) | No | ||
usually Nocardia asteroides and other Nocardia species | Nocardiosis | chest x-ray to analyze the lungs, a bronchoscopy, a brain/lung/skin biopsy, or a sputum culture. | trimethoprim/sulfamethoxazole or high doses of sulfonamides | No |
Onchocerca volvulus | Onchocerciasis (River blindness) | Under research [32] | ||
Opisthorchis viverrini and Opisthorchis felineus | Opisthorchiasis | No | ||
Paracoccidioides brasiliensis | Paracoccidioidomycosis (South American blastomycosis) | No | ||
usually Paragonimus westermani and other Paragonimus species | Paragonimiasis | No | ||
Pasteurella species | Pasteurellosis | No | ||
Pediculus humanus capitis | Pediculosis capitis (Head lice) | No | ||
Pediculus humanus corporis | Pediculosis corporis (Body lice) | No | ||
Pthirus pubis | Pediculosis pubis (pubic lice, crab lice) | No | ||
multiple | Pelvic inflammatory disease (PID) | Based on symptoms, ultrasound, laparoscopic surgery | Typical regimens include cefoxitin or cefotetan plus doxycycline, and clindamycin plus gentamicin. | No |
Bordetella pertussis | Pertussis (whooping cough) | Nasopharyngeal swab | erythromycin, clarithromycin, or azithromycin | Yes |
Yersinia pestis | Plague | Finding the bacterium in a lymph node, blood, sputum | Gentamicin and a fluoroquinolone | Under research [6] |
Streptococcus pneumoniae | Pneumococcal infection | Culture | cephalosporins, and fluoroquinolones such as levofloxacin and moxifloxacin | Yes |
Pneumocystis jirovecii | Pneumocystis pneumonia (PCP) | chest X-ray and an arterial oxygen level | trimethoprim/sulfamethoxazole | No |
multiple | Pneumonia | Based on symptoms, chest X-ray | Antibiotics, antivirals, oxygen therapy | No |
Poliovirus | Poliomyelitis | Finding the virus in the feces or antibodies in the blood | supportive care | Yes |
Prevotella species | Prevotella infection | No | ||
usually Naegleria fowleri | Primary amoebic meningoencephalitis (PAM) | flagellation test | Miltefosine, fluconazole, amphotericin B, posaconazole, voriconazole, targeted temperature management | No |
JC virus | Progressive multifocal leukoencephalopathy | finding JC virus DNA in spinal fluid, brain CT | No | |
Chlamydophila psittaci | Psittacosis | Culture | tetracyclines and chloramphenicol | No |
Coxiella burnetii | Q fever | Based on serology | doxycycline, tetracycline, chloramphenicol, ciprofloxacin, and ofloxacin | Yes |
Rabies virus | Rabies | fluorescent antibody test (FAT) | Supportive care | Yes |
Borrelia hermsii , Borrelia recurrentis , and other Borrelia species | Relapsing fever | blood smear | Tetracycline-class antibiotics | No |
Respiratory syncytial virus (RSV) | Respiratory syncytial virus infection | A variety of laboratory tests | Treatment for RSV infection is focused primarily on supportive care. | Under research [33] |
Rhinosporidium seeberi | Rhinosporidiosis | No | ||
Rhinovirus | Rhinovirus infection | No | ||
Rickettsia species | Rickettsial infection | No | ||
Rickettsia akari | Rickettsialpox | No | ||
Rift Valley fever virus | Rift Valley fever (RVF) | No | ||
Rickettsia rickettsii | Rocky Mountain spotted fever (RMSF) | No | ||
Rotavirus | Rotavirus infection | Yes | ||
Rubella virus | Rubella | Yes | ||
Salmonella species | Salmonellosis | No | ||
SARS coronavirus | Severe acute respiratory syndrome (SARS) | Under research [34] | ||
Sarcoptes scabiei | Scabies | No | ||
Group A Streptococcus species | Scarlet fever | No | ||
Schistosoma species | Schistosomiasis | Under research [35] | ||
multiple | Sepsis | No | ||
Shigella species | Shigellosis (bacillary dysentery) | No | ||
Varicella zoster virus (VZV) | Shingles (Herpes zoster) | Yes [36] | ||
Variola major or Variola minor | Smallpox (variola) | Yes | ||
Sporothrix schenckii | Sporotrichosis | No | ||
Staphylococcus species | Staphylococcal food poisoning | No | ||
Staphylococcus species | Staphylococcal infection | No | ||
Strongyloides stercoralis | Strongyloidiasis | No | ||
Measles virus | Subacute sclerosing panencephalitis | Yes | ||
Treponema pallidum | Bejel, Syphilis, and Yaws | Under research [37] | ||
Taenia species | Taeniasis | No | ||
Clostridium tetani | Tetanus (lockjaw) | Yes | ||
Tick-borne encephalitis virus (TBEV) | Tick-borne encephalitis | Yes | ||
usually Trichophyton species | Tinea barbae (barber's itch) | No | ||
usually Trichophyton tonsurans | Tinea capitis (ringworm of the scalp) | No | ||
usually Trichophyton species | Tinea corporis (ringworm of the body) | No | ||
usually Epidermophyton floccosum , Trichophyton rubrum , and Trichophyton mentagrophytes | Tinea cruris (Jock itch) | No | ||
Trichophyton rubrum | Tinea manum (ringworm of the hand) | No | ||
usually Hortaea werneckii | Tinea nigra | No | ||
usually Trichophyton species | Tinea pedis (athlete's foot) | No | ||
usually Trichophyton species | Tinea unguium (onychomycosis) | No | ||
Malassezia species | Tinea versicolor (Pityriasis versicolor) | No | ||
Staphylococcus aureus or Streptococcus pyogenes | Toxic shock syndrome (TSS) | Under research [38] [39] | ||
Toxocara canis or Toxocara cati | Toxocariasis (ocular larva migrans (OLM)) | No | ||
Toxocara canis or Toxocara cati | Toxocariasis (visceral larva migrans (VLM)) | No | ||
Toxoplasma gondii | Toxoplasmosis | No | ||
Chlamydia trachomatis | Trachoma | No | ||
Trichinella spiralis | Trichinosis | No | ||
Trichomonas vaginalis | Trichomoniasis | No | ||
Trichuris trichiura | Trichuriasis (whipworm infection) | No | ||
usually Mycobacterium tuberculosis | Tuberculosis | Yes | ||
Francisella tularensis | Tularemia | Under research [40] | ||
Salmonella enterica subsp. enterica, serovar typhi | Typhoid fever | Yes | ||
Rickettsia | Typhus fever | No | ||
Ureaplasma urealyticum | Ureaplasma urealyticum infection | No | ||
Coccidioides immitis or Coccidioides posadasii . [41] | Valley fever | No | ||
Venezuelan equine encephalitis virus | Venezuelan equine encephalitis | No | ||
Guanarito virus | Venezuelan hemorrhagic fever | No | ||
Vibrio vulnificus | Vibrio vulnificus infection | No | ||
Vibrio parahaemolyticus | Vibrio parahaemolyticus enteritis | No | ||
multiple viruses | Viral pneumonia | No | ||
West Nile virus | West Nile fever | Under research [42] | ||
Trichosporon beigelii | White piedra (tinea blanca) | No | ||
Yersinia pseudotuberculosis | Yersinia pseudotuberculosis infection | No | ||
Yersinia enterocolitica | Yersiniosis | No | ||
Yellow fever virus | Yellow fever | Yes | ||
Zeaspora fungus | Zeaspora | No | ||
Zika virus | Zika fever | Under research [43] | ||
Mucorales order (Mucormycosis) and Entomophthorales order (Entomophthoramycosis) | Zygomycosis | No |
A vaccine is a biological preparation that provides active acquired immunity to a particular infectious or malignant disease. The safety and effectiveness of vaccines has been widely studied and verified. A vaccine typically contains an agent that resembles a disease-causing microorganism and is often made from weakened or killed forms of the microbe, its toxins, or one of its surface proteins. The agent stimulates the body's immune system to recognize the agent as a threat, destroy it, and recognize further and destroy any of the microorganisms associated with that agent that it may encounter in the future.
Rotaviruses are the most common cause of diarrhoeal disease among infants and young children. Nearly every child in the world is infected with a rotavirus at least once by the age of five. Immunity develops with each infection, so subsequent infections are less severe. Adults are rarely affected. Rotavirus is a genus of double-stranded RNA viruses in the family Reoviridae. There are nine species of the genus, referred to as A, B, C, D, F, G, H, I and J. Rotavirus A is the most common species, and these rotaviruses cause more than 90% of rotavirus infections in humans.
Hepatitis E is inflammation of the liver caused by infection with the hepatitis E virus (HEV); it is a type of viral hepatitis. Hepatitis E has mainly a fecal-oral transmission route that is similar to hepatitis A, although the viruses are unrelated. HEV is a positive-sense, single-stranded, nonenveloped, RNA icosahedral virus and one of five known human hepatitis viruses: A, B, C, D, and E.
Arbovirus is an informal name for any virus that is transmitted by arthropod vectors. The term arbovirus is a portmanteau word. Tibovirus is sometimes used to more specifically describe viruses transmitted by ticks, a superorder within the arthropods. Arboviruses can affect both animals and plants. In humans, symptoms of arbovirus infection generally occur 3–15 days after exposure to the virus and last three or four days. The most common clinical features of infection are fever, headache, and malaise, but encephalitis and viral hemorrhagic fever may also occur.
Human metapneumovirus is a negative-sense single-stranded RNA virus of the family Pneumoviridae and is closely related to the avian metapneumovirus (AMPV) subgroup C. It was isolated for the first time in 2001 in the Netherlands by using the RAP-PCR technique for the identification of unknown viruses growing in cultured cells. As of 2016, it was the second most common cause—after respiratory syncytial virus (RSV)—of acute respiratory tract illness in otherwise-healthy children under the age of 5 in a large US outpatient clinic.
Orthomyxoviridae is a family of negative-sense RNA viruses. It includes seven genera: Alphainfluenzavirus, Betainfluenzavirus, Gammainfluenzavirus, Deltainfluenzavirus, Isavirus, Thogotovirus, and Quaranjavirus. The first four genera contain viruses that cause influenza in birds and mammals, including humans. Isaviruses infect salmon; the thogotoviruses are arboviruses, infecting vertebrates and invertebrates. The Quaranjaviruses are also arboviruses, infecting vertebrates (birds) and invertebrates (arthropods).
Murine respirovirus, formerly Sendai virus (SeV) and previously also known as murine parainfluenza virus type 1 or hemagglutinating virus of Japan (HVJ), is an enveloped, 150-200 nm–diameter, negative sense, single-stranded RNA virus of the family Paramyxoviridae. It typically infects rodents and it is not pathogenic for humans or domestic animals.
Palivizumab, sold under the brand name Synagis, is a monoclonal antibody produced by recombinant DNA technology used to prevent severe disease caused by respiratory syncytial virus (RSV) infections. It is recommended for infants at high-risk for RSV due to conditions such as prematurity or other medical problems including heart or lung diseases.
Antibody-dependent enhancement (ADE), sometimes less precisely called immune enhancement or disease enhancement, is a phenomenon in which binding of a virus to suboptimal antibodies enhances its entry into host cells, followed by its replication. The suboptimal antibodies can result from natural infection or from vaccination. ADE may cause enhanced respiratory disease, but is not limited to respiratory disease. It has been observed in HIV, RSV, and Dengue virus and is monitored for in vaccine development.
An attenuated vaccine is a vaccine created by reducing the virulence of a pathogen, but still keeping it viable. Attenuation takes an infectious agent and alters it so that it becomes harmless or less virulent. These vaccines contrast to those produced by "killing" the pathogen.
Anthony Charles Minson is a British virologist known for his work on the biology of herpesviruses, and a university administrator. He was the Senior Pro-Vice-Chancellor of the University of Cambridge from 2003 to 2009. He is an emeritus professor of virology at the university's Department of Pathology and an emeritus fellow of Wolfson College.
Adolfo García-Sastre,(born in Burgos, 10 October 1964) is a Spanish professor of Medicine and Microbiology and co-director of the Global Health & Emerging Pathogens Institute at the Icahn School of Medicine at Mount Sinai in New York City. His research into the biology of influenza viruses has been at the forefront of medical advances in epidemiology.
Herpes simplex research includes all medical research that attempts to prevent, treat, or cure herpes, as well as fundamental research about the nature of herpes. Examples of particular herpes research include drug development, vaccines and genome editing. HSV-1 and HSV-2 are commonly thought of as oral and genital herpes respectively, but other members in the herpes family include chickenpox (varicella/zoster), cytomegalovirus, and Epstein-Barr virus. There are many more virus members that infect animals other than humans, some of which cause disease in companion animals or have economic impacts in the agriculture industry.
Alphacoronavirus chicagoense is a species of coronavirus which infects humans and bats. It is an enveloped, positive-sense, single-stranded RNA virus which enters its host cell by binding to the APN receptor. Along with Human coronavirus OC43, it is one of the viruses responsible for the common cold. HCoV-229E is a member of the genus Alphacoronavirus and subgenus Duvinacovirus.
M. Juliana "Julie" McElrath is a senior vice president and director of the vaccine and infectious disease division at Fred Hutchinson Cancer Research Center and the principal investigator of the HIV Vaccine Trials Network Laboratory Center in Seattle, Washington. She is also a professor at the University of Washington.
A universal flu vaccine would be a flu vaccine effective against all human-adapted strains of influenza A and influenza B regardless of the virus sub type, or any antigenic drift or antigenic shift. Hence it should not require modification from year to year in order to keep up with changes in the influenza virus. As of 2024 no universal flu vaccine had been successfully developed, however several candidate vaccines were in development, with some undergoing early stage clinical trial.
An mRNAvaccine is a type of vaccine that uses a copy of a molecule called messenger RNA (mRNA) to produce an immune response. The vaccine delivers molecules of antigen-encoding mRNA into cells, which use the designed mRNA as a blueprint to build foreign protein that would normally be produced by a pathogen or by a cancer cell. These protein molecules stimulate an adaptive immune response that teaches the body to identify and destroy the corresponding pathogen or cancer cells. The mRNA is delivered by a co-formulation of the RNA encapsulated in lipid nanoparticles that protect the RNA strands and help their absorption into the cells.
A viral vector vaccine is a vaccine that uses a viral vector to deliver genetic material (DNA) that can be transcribed by the recipient's host cells as mRNA coding for a desired protein, or antigen, to elicit an immune response. As of April 2021, six viral vector vaccines, four COVID-19 vaccines and two Ebola vaccines, have been authorized for use in humans.
A genetic vaccine is a vaccine that contains nucleic acids such as DNA or RNA that lead to protein biosynthesis of antigens within a cell. Genetic vaccines thus include DNA vaccines, RNA vaccines and viral vector vaccines.
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