VN1R1

VN1R1
Identifiers
Aliases	VN1R1 , V1RL1, VNR19I1, ZVNH1, ZVNR1, vomeronasal 1 receptor 1
External IDs	OMIM: 605234 HomoloGene: 110801 GeneCards: VN1R1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	57,457,140 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• G protein-coupled receptor activity ; • pheromone receptor activity ; • signal transducer activity ; • pheromone binding ;
Cellular component	• integral component of membrane ; • plasma membrane ; • membrane ;
Biological process	• G protein-coupled receptor signaling pathway ; • response to pheromone ; • signal transduction ; • sensory perception of chemical stimulus ; • biological process ;
	Sources:Amigo / QuickGO
Orthologs
	57191
	n/a
	ENSG00000178201
	n/a
	Q9GZP7
	n/a
	NM_020633
	n/a
	NP_065684
	n/a
	Wikidata
View/Edit Human

Last updated July 19, 2021

Vomeronasal type-1 receptor 1 is a protein that in humans is encoded by the VN1R1 gene.^[3]^[4]

Function

Pheromones are chemical signals that elicit specific behavioral responses and physiologic alterations in recipients of the same species. The protein encoded by this gene is similar to pheromone receptors and is primarily localized to the olfactory mucosa. An alternate splice variant of this gene is thought to exist, but its full length nature has not been determined.^[4]

Ligands

Hedione ^[5]
Iso E Super ^[6]

Related Research Articles

The vomeronasal organ (VNO), or Jacobson's organ, is the paired auxiliary olfactory (smell) sense organ located in the soft tissue of the nasal septum, in the nasal cavity just above the roof of the mouth. The name is derived from the fact that it lies adjacent to the unpaired vomer bone in the nasal septum. It is present and functional in all snakes and lizards, and in many mammals, including cats, dogs, cattle, pigs, and some primates; in humans it is present, but is vestigial and non-functional.

Olfactory receptors (ORs), also known as odorant receptors, are chemoreceptors expressed in the cell membranes of olfactory receptor neurons and are responsible for the detection of odorants which give rise to the sense of smell. Activated olfactory receptors trigger nerve impulses which transmit information about odor to the brain. These receptors are members of the class A rhodopsin-like family of G protein-coupled receptors (GPCRs). The olfactory receptors form a multigene family consisting of around 800 genes in humans and 1400 genes in mice.

Vomeronasal type-1 receptor 2 is a protein that in humans is encoded by the VN1R2 gene.

Vomeronasal type-1 receptor 3 is a protein that is encoded by the VN1R3 gene in humans.

Vomeronasal type-1 receptor 4 is a protein that in humans is encoded by the VN1R4 gene.

Vomeronasal type-1 receptor 5 is a protein that in humans is encoded by the VN1R5 gene.

Olfactory receptor 1D2 is a protein that in humans is encoded by the OR1D2 gene.

Olfactory receptor 2H2 is a protein that in humans is encoded by the OR2H2 gene.

Olfactory receptor 1A1 is a protein that in humans is encoded by the OR1A1 gene.

Olfactory receptor 1E1 is a protein that in humans is encoded by the OR1E1 gene.

Olfactory receptor 6A2 is a protein that in humans is encoded by the OR6A2 gene.

Olfactory receptor 1A2 is a protein that in humans is encoded by the OR1A2 gene.

Olfactory receptor 2K2 is a protein that in humans is encoded by the OR2K2 gene.

Olfactory receptor 2S2 is a protein that in humans is encoded by the OR2S2 gene.

Olfactory receptor 7D4 is a protein that in humans is encoded by the OR7D4 gene.

Olfactory receptor 13C4 is a protein that in humans is encoded by the OR13C4 gene.

Olfactory receptor 13C8 is a protein that in humans is encoded by the OR13C8 gene.

Olfactory receptor 13H1 is a protein that in humans is encoded by the OR13H1 gene.

Olfactory receptor 13C2 is a protein that in humans is encoded by the OR13C2 gene.

Vomeronasal receptors are a class of olfactory receptors that putatively function as receptors for pheromones. Pheromones have evolved in all animal phyla, to signal sex and dominance status, and are responsible for stereotypical social and sexual behaviour among members of the same species. In mammals, these chemical signals are believed to be detected primarily by the vomeronasal organ (VNO), a chemosensory organ located at the base of the nasal septum.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000178201 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Rodriguez I, Greer CA, Mok MY, Mombaerts P (September 2000). "A putative pheromone receptor gene expressed in human olfactory mucosa". Nature Genetics. 26 (1): 18–9. doi:10.1038/79124. PMID 10973240. S2CID 21063460.
1 2 "Entrez Gene: VN1R1 vomeronasal 1 receptor 1".
↑ Wallrabenstein I, Gerber J, Rasche S, Croy I, Kurtenbach S, Hummel T, Hatt H (June 2015). "The smelling of Hedione results in sex-differentiated human brain activity". NeuroImage. 113: 365–73. doi:10.1016/j.neuroimage.2015.03.029. PMID 25797832. S2CID 6526522.
↑ Ouyang J, Bae H, Jordi S, Dao QM, Dossenbach S, Dehn S, Lingnau JB, Kanta De C, Kraft P, List B (Feb 2021). "The Smelling Principle of Vetiver Oil, Unveiled by Chemical Synthesis". Angew Chem Int Ed Engl. 11. doi:10.1002/anie.202014609. PMC 7986879 . PMID 33315304. (reference 30)

Giorgi D, Friedman C, Trask BJ, Rouquier S (December 2000). "Characterization of nonfunctional V1R-like pheromone receptor sequences in human". Genome Research. 10 (12): 1979–85. doi:10.1101/gr.10.12.1979. PMC 313059 . PMID 11116092.
Pantages E, Dulac C (December 2000). "A novel family of candidate pheromone receptors in mammals". Neuron. 28 (3): 835–45. doi: 10.1016/S0896-6273(00)00157-4 . PMID 11163270. S2CID 15023062.
Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (June 2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters. 520 (1–3): 97–101. doi: 10.1016/S0014-5793(02)02775-8 . PMID 12044878. S2CID 7116392.
Zhang J, Webb DM (July 2003). "Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates". Proceedings of the National Academy of Sciences of the United States of America. 100 (14): 8337–41. Bibcode:2003PNAS..100.8337Z. doi:10.1073/pnas.1331721100. PMC 166230 . PMID 12826614.
Mitropoulos C, Papachatzopoulou A, Menounos PG, Kolonelou C, Pappa M, Bertolis G, Gerou S, Patrinos GP (2007). "Association study of human VN1R1 pheromone receptor gene alleles and gender". Genetic Testing. 11 (2): 128–32. doi:10.1089/gte.2006.0516. PMID 17627382.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000178201 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10973240-3] Rodriguez I, Greer CA, Mok MY, Mombaerts P (September 2000). "A putative pheromone receptor gene expressed in human olfactory mucosa". Nature Genetics. 26 (1): 18–9. doi:10.1038/79124. PMID 10973240. S2CID 21063460.

[entrez-4] 1 2 "Entrez Gene: VN1R1 vomeronasal 1 receptor 1".

[Wallrabenstein_2015-5] Wallrabenstein I, Gerber J, Rasche S, Croy I, Kurtenbach S, Hummel T, Hatt H (June 2015). "The smelling of Hedione results in sex-differentiated human brain activity". NeuroImage. 113: 365–73. doi:10.1016/j.neuroimage.2015.03.029. PMID 25797832. S2CID 6526522.

[Ouyang_2021-6] Ouyang J, Bae H, Jordi S, Dao QM, Dossenbach S, Dehn S, Lingnau JB, Kanta De C, Kraft P, List B (Feb 2021). "The Smelling Principle of Vetiver Oil, Unveiled by Chemical Synthesis". Angew Chem Int Ed Engl. 11. doi:10.1002/anie.202014609. PMC 7986879 . PMID 33315304. (reference 30)

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VN1R1

Contents

Function

Ligands

Related Research Articles

References

Further reading