Frizzled-6

FZD6
Identifiers
Aliases	FZD6 , FZ-6, FZ6, HFZ6, NDNC10, frizzled class receptor 6, NDNC1
External IDs	OMIM: 603409; MGI: 108474; HomoloGene: 2617; GeneCards: FZD6; OMA:FZD6 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q22.3 Start 103,298,433 bp [1] End 103,332,866 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15 B3.1|15 15.22 cM Start 38,869,429 bp [2] End 38,901,583 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell caput epididymis Epithelium of choroid plexus skin of thigh skin of hip corpus epididymis epithelium of nasopharynx palpebral conjunctiva secondary oocyte hair follicle Top expressed in lip uterus genital tubercle lens esophagus zone of skin heart spermatocyte urethra lower respiratory tract More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity protein binding Wnt-activated receptor activity ubiquitin protein ligase binding transmembrane signaling receptor activity G protein-coupled receptor activity Wnt-protein binding amyloid-beta binding Cellular component membrane apical part of cell integral component of plasma membrane cell surface apicolateral plasma membrane apical plasma membrane cytoplasmic vesicle membrane cytoplasmic vesicle plasma membrane integral component of membrane Biological process hair follicle development G protein-coupled receptor signaling pathway non-canonical Wnt signaling pathway establishment of planar polarity cell proliferation in midbrain Wnt signaling pathway negative regulation of DNA-binding transcription factor activity platelet activation multicellular organism development Wnt signaling pathway, planar cell polarity pathway embryonic nail plate morphogenesis cell surface receptor signaling pathway neural tube closure inner ear morphogenesis midbrain morphogenesis negative regulation of canonical Wnt signaling pathway signal transduction midbrain development Wnt signaling pathway, calcium modulating pathway establishment of body hair planar orientation canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8323 14368 Ensembl ENSG00000164930 ENSMUSG00000022297 UniProt O60353 Q61089 RefSeq (mRNA) NM_001164615 NM_001164616 NM_003506 NM_001317796 NM_001162494 NM_008056 RefSeq (protein) NP_001158087 NP_001158088 NP_001304725 NP_003497 NP_001158087.1 NP_003497.2 NP_001155966 NP_032082 Location (UCSC) Chr 8: 103.3 – 103.33 Mb Chr 15: 38.87 – 38.9 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Frizzled-6(Fz-6) is a protein that in humans is encoded by the FZD6 gene. ^{[5] [6] [7]}

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for WNT signaling proteins. The FZD6 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and 7 transmembrane domains. However, unlike many other FZD family members, FDZ6 does not contain a C-terminal PDZ domain-binding motif. ^[7] Fz-6 is believed to be the receptor for the WNT4 ligand. ^[8]

Interactions

Fz-6 has been shown to interact with secreted frizzled-related protein 1. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000164930 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022297 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tokuhara M, Hirai M, Atomi Y, Terada M, Katoh M (Feb 1998). "Molecular cloning of human Frizzled-6". Biochemical and Biophysical Research Communications. 243 (2): 622–7. doi:10.1006/bbrc.1998.8143. PMID   9480858.
6. Golan T, Yaniv A, Bafico A, Liu G, Gazit A (Apr 2004). "The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade". The Journal of Biological Chemistry. 279 (15): 14879–88. doi: 10.1074/jbc.M306421200 . PMID   14747478.
7. "Entrez Gene: FZD6 frizzled homolog 6 (Drosophila)".
8. Lyons JP, Mueller UW, Ji H, Everett C, Fang X, Hsieh JC, Barth AM, McCrea PD (Aug 2004). "Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells". Experimental Cell Research. 298 (2): 369–87. doi:10.1016/j.yexcr.2004.04.036. PMID   15265686.
9. Bafico A, Gazit A, Pramila T, Finch PW, Yaniv A, Aaronson SA (Jun 1999). "Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling". The Journal of Biological Chemistry. 274 (23): 16180–7. doi: 10.1074/jbc.274.23.16180 . PMID   10347172.

Further reading

• Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J (Feb 1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled". The Journal of Biological Chemistry. 271 (8): 4468–76. doi: 10.1074/jbc.271.8.4468 . PMID   8626800.
• Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS (Jun 1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proceedings of the National Academy of Sciences of the United States of America. 94 (13): 6770–5. Bibcode:1997PNAS...94.6770F. doi: 10.1073/pnas.94.13.6770 . PMC   21233 . PMID   9192640.
• Bafico A, Gazit A, Pramila T, Finch PW, Yaniv A, Aaronson SA (Jun 1999). "Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling". The Journal of Biological Chemistry. 274 (23): 16180–7. doi: 10.1074/jbc.274.23.16180 . PMID   10347172.
• Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y (Jun 2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genetics. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID   15370539. S2CID   32817238.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Sirchia R, Luparello C (May 2007). "Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells". Biological Chemistry. 388 (5): 457–65. doi:10.1515/BC.2007.059. PMID   17516841. S2CID   2286919.

External links

• "Frizzled Receptors: FZD₆". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-01-24. Retrieved 2008-12-04.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.