LGR6

LGR6
Identifiers
Aliases	LGR6 , GPCR, VTS20631, leucine-rich repeat containing G protein-coupled receptor 6, leucine rich repeat containing G protein-coupled receptor 6
External IDs	OMIM: 606653 MGI: 2441805 HomoloGene: 49680 GeneCards: LGR6
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q32.1 Start 202,193,799 bp [1] End 202,319,781 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 E4 Start 134,911,039 bp [2] End 135,033,014 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right coronary artery ascending aorta left coronary artery gastric mucosa popliteal artery anterior pituitary right uterine tube gallbladder lactiferous duct tibia Top expressed in ascending aorta aortic valve molar secondary oocyte right ventricle median eminence skin of back epidermis myocardium of ventricle hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding G protein-coupled receptor activity transmembrane signaling receptor activity signal transducer activity protein-hormone receptor activity heparin binding Roundabout binding Cellular component integral component of membrane vesicle plasma membrane integral component of plasma membrane trans-Golgi network membrane membrane extracellular space Biological process positive regulation of canonical Wnt signaling pathway positive regulation of Wnt signaling pathway G protein-coupled receptor signaling pathway Wnt signaling pathway signal transduction positive regulation of cell migration tissue regeneration bone regeneration axon guidance negative chemotaxis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 59352 329252 Ensembl ENSG00000133067 ENSMUSG00000042793 UniProt Q9HBX8 Q3UVD5 RefSeq (mRNA) NM_001017403 NM_001017404 NM_021636 NM_001033409 RefSeq (protein) NP_001017403 NP_001017404 NP_067649 NP_001028581 Location (UCSC) Chr 1: 202.19 – 202.32 Mb Chr 1: 134.91 – 135.03 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Leucine-rich repeat-containing G-protein coupled receptor 6 is a protein that in humans is encoded by the LGR6 gene. ^{[5] [6]} Along with the other G-protein coupled receptors LGR4 and LGR5, LGR6 is a Wnt signaling pathway mediator. LGR6 also acts as an epithelial stem cell marker in squamous cell carcinoma in mice in vivo. ^[7]

This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000133067 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042793 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hsu SY, Kudo M, Chen T, Nakabayashi K, Bhalla A, van der Spek PJ, van Duin M, Hsueh AJ (Jan 2001). "The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7". Mol Endocrinol. 14 (8): 1257–71. doi: 10.1210/me.14.8.1257 . PMID   10935549.
6. "Entrez Gene: LGR6 leucine-rich repeat-containing G protein-coupled receptor 6".
7. Huang, Phillips Y.; Kandyba, Eve; Jabouille, Arnaud; Sjolund, Jonas; Kumar, Atul; Halliwill, Kyle; McCreery, Melissa; DelRosario, Reyno; Kang, Hio Chung (2017). "Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma". Nature Genetics. 49 (11): 1624–1632. doi:10.1038/ng.3957. PMC   5662105 . PMID   28945253.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID   12044878. S2CID   7116392.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.